Mini Nutritional Assessment (MNA) and biochemical markers of cachexia in metastatic lung cancer patients: Interrelations and associations with prognosis
Mini Nutritional Assessment (MNA) and biochemical markers of cachexia in metastatic lung cancer patients: Interrelations and associations with prognosis
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DOI：
10.1016/j.lungcan.2011.05.009
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发表时间：
2011-12-01
期刊：
影响因子：
5.3
通讯作者：
Georgoulias, Vassilis
中科院分区：
文献类型：
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作者：
Gioulbasanis, Ioannis;Georgoulias, Panagiotis;Georgoulias, Vassilis
目的：肺癌患者在恶病质综合征的背景下经常出现体重减轻。尽管恶病质具有很高的临床意义，但目前仍缺乏明确的诊断标准。营养筛查问卷，如迷你营养评估（MNA），已被提出及时诊断综合征。本研究的目的是评估MNA与转移性肺癌患者炎症/恶病质实验室标志物的相关性。测量参数的预后价值也examined.Patients和方法：转移性肺癌患者全身治疗的资格。记录基线临床特征，并使用MNA评估营养状况。结果：共纳入115例患者（男性101例），中位年龄66岁（32-86岁）。根据MNA评分，27例（23.5%）患者营养良好，59例（51.3%）患者存在营养风险，29例（25.2%）患者在诊断时已经营养不良。MNA与以下参数相关：Hb（p = 0.001）、白蛋白（p < 0.001）、CRP（p = 0.002）、脂联素（p = 0.037）和瘦素（p = 0.008）。中位随访38.2个月后，多变量分析显示，年龄（p = 0.008），转移部位（p < 0.001），MNA（p = 0.044）和瘦素（p = 0.004）独立相关的总survival.Conclusions：基于MNA，大多数患者营养不良或营养风险。MNA与炎症/恶病质相关的实验室参数相关，与生存率独立相关。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
Purpose: Lung cancer patients frequently present with weight loss in the context of the cachexia syndrome. Despite its high clinical significance, definite diagnostic criteria of cachexia are lacking. Nutritional screening questionnaires, like the Mini Nutritional Assessment (MNA), have been proposed for the timely diagnosis of the syndrome. The aim of this study was to evaluate the correlation of MNA with laboratory markers of inflammation/cachexia in patients with metastatic lung cancer. The prognostic value of the measured parameters was also examined.Patients and methods: Patients with metastatic lung cancer referred for systemic therapy were eligible. Baseline clinical characteristics were recorded and nutritional status was assessed using MNA. Blood samples were also collected and the following parameters were measured: hemoglobin (Hb), albumin (Alb), C-reactive protein (CRP), ghrelin, adiponectin, leptin and insulin growth factor I (IGF-I).Results: Totally, 115 patients (101 males) [median age 66 years (range 32-86)] were evaluated. According to MNA score, 27 (23.5%) patients were well nourished, 59(51.3%) were at nutritional risk and 29(25.2%) were already malnourished at diagnosis. MNA correlated with the following parameters: Hb (p = 0.001), albumin (p < 0.001), CRP (p = 0.002), adiponectin (p = 0.037) and leptin (p = 0.008). After a median follow up of 38.2 months, multivariate analysis revealed that age (p = 0.008), number of metastatic sites (p < 0.001), MNA (p = 0.044) and leptin (p = 0.004) independently correlated with overall survival.Conclusions: Based on the MNA, the majority of patients were either malnourished or at nutritional risk. MNA correlated with laboratory parameters related to inflammation/cachexia and was independently associated with survival. (C) 2011 Elsevier Ireland Ltd. All rights reserved.