Insights into the biology and treatment strategies of pancreatic neuroendocrine tumors.
Insights into the biology and treatment strategies of pancreatic neuroendocrine tumors.
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DOI：
10.21037/apc.2019.06.02
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发表时间：
2019-06-01
期刊：
影响因子：
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通讯作者：
Nancy Du, Yi-Chieh
中科院分区：
文献类型：
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作者：
Buicko, Jessica L;Finnerty, Brendan M;Nancy Du, Yi-Chieh
胰腺神经内分泌肿瘤是继胰腺导管腺癌之后第二常见的原发性胰腺肿瘤。PNS临床表现多样，生存率低。下一代测序的最新进展显着增加了我们对PNTR分子景观的理解，并有助于指导靶向治疗的发展。本综述旨在通过讨论目前对PNDV的临床表现、最新治疗策略、新型小鼠模型和分子生物学的理解，概述PNDV的整体情况。此外，我们还将深入了解未来开发更有效的靶向治疗方法，这些治疗方法是管理PNTR所必需的。
Pancreatic neuroendocrine tumors (PNETs) are the second most common primary pancreatic neoplasms after pancreatic ductal adenocarcinoma. PNETs present with widely various clinical manifestation and unfavorable survival rate. The recent advances in next generation sequencing have significantly increased our understanding of the molecular landscape of PNETs and help guide the development of targeted therapies. This review intends to outline a holistic picture of the tumors by discussing current understanding of clinical presentations, up-to-date treatment strategies, novel mouse models, and molecular biology of PNETs. Furthermore, we will provide insight into the future development of more effective targeted therapies that are necessary to manage PNETs.