The orexin system: roles in sleep/wake regulation
The orexin system: roles in sleep/wake regulation
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DOI：
10.1111/j.1749-6632.2010.05513.x
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发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Tsujino, Natsuko
中科院分区：
文献类型：
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作者：
Sakurai, Takeshi;Mieda, Michihiro;Tsujino, Natsuko
下丘脑神经元产生的神经肽食欲素A和食欲素B是睡眠/觉醒状态的关键调节剂。食欲素信号传导的缺乏导致人、狗和啮齿动物中的发作性睡病表型。近年来，越来越多的证据表明，食欲素系统通过与情绪、奖赏和能量稳态密切相关的神经系统相互作用来调节睡眠和觉醒。在这篇综述中，我们将讨论目前对食欲素系统生理学的理解，特别是关注其在睡眠/觉醒状态调节中的作用。
The neuropeptides orexin A and orexin B, produced in hypothalamic neurons, are critical regulators of sleep/wake states. Deficiency of orexin signaling results in narcoleptic phenotype in humans, dogs, and rodents. Recently, accumulating evidence has indicated that the orexin system regulates sleep and wakefulness through interactions with neuronal systems that are closely related with emotion, reward, and energy homeostasis. In this review, we will discuss the current understanding of the physiology of the orexin system especially focusing on its roles in the regulation of sleep/wakefulness states.