MRI estimation of gadolinium and albumin effects on water proton
MRI estimation of gadolinium and albumin effects on water proton
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DOI：
10.1016/j.neuroimage.2010.05.032
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发表时间：
2011-01-01
期刊：
影响因子：
5.7
通讯作者：
Ewing, James R.
中科院分区：
文献类型：
--
作者：
Bagher-Ebadian, Hassan;Paudyal, Ramesh;Ewing, James R.
在7T下，测量了Gd-螯合-白蛋白化合物在水中质子的纵向弛豫度随交联基质大分子含量的变化。结果表明，Gd对水质子弛豫度的影响不是恒定的，随牛血清白蛋白(BSA)浓度的增加而适度升高。在牛血清白蛋白浓度的0%-25%范围内观察到了约35%的变化(R=3.893+0.0502×牛血清白蛋白[%]，SE-.0119和0.1740，t-4.215和22.383，p
The longitudinal relaxivity on the protons of water of a Gd-chelate-albumin compound was measured at 7 T as a function of the macromolecular content of a cross-linked matrix. In agreement with previous works, the results demonstrate that the effect of gadolinium on water proton relaxivity is not constant, rising moderately with increase in the concentration of bovine serum albumin (BSA). About 35% variation in relaxivity was observed over a 0%-25% range of BSA concentrations (R = 3.893 + 0.0502 x BSA [%], SE-.0119 and 0.1740, t-4.215 and 22.383, p