MRI and CSF biomarkers in normal, MCI, and AD subjects Diagnostic discrimination and cognitive correlations
MRI and CSF biomarkers in normal, MCI, and AD subjects Diagnostic discrimination and cognitive correlations
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DOI：
10.1212/wnl.0b013e3181af79e5
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发表时间：
2009-07-28
期刊：
影响因子：
9.9
通讯作者：
Jack, C. R., Jr.
中科院分区：
文献类型：
--
作者：
Vemuri, P.;Wiste, H. J.;Jack, C. R., Jr.
目的：评估MRI和CSF生物标志物与认知正常（CN）受试者和遗忘型轻度认知功能障碍（aMCI）和阿尔茨海默病（AD）患者的临床诊断和认知表现的相关性：这是一项横断面研究，数据来自阿尔茨海默病神经影像学倡议，其中包括CN受试者，aMCI受试者和AD受试者的CSF和MRI。在399例受试者（109例CN，192例aMCI，98例AD）中获得了基线CSF（t-tau、A β（1-42）和p-tau（181 P））和MRI扫描。结构异常指数（STAND）评分，反映程度的AD样解剖特征的MRI，计算为每个subject.Results：我们发现没有显着的相关性之间的CSF生物标志物和认知评分在任何3个临床组单独。相反，在aMCI和AD中，STAND评分与临床痴呆评分总和和简易精神状态检查相关（p
Objective: To assess the correlations of both MRI and CSF biomarkers with clinical diagnosis and with cognitive performance in cognitively normal (CN) subjects and patients with amnestic mild cognitive impairment (aMCI) and Alzheimer disease (AD).Methods: This is a cross-sectional study with data from the Alzheimer's Disease Neuroimaging Initiative, which consists of CN subjects, subjects with aMCI, and subjects with AD with both CSF and MRI. Baseline CSF (t-tau, A beta(1-42), and p-tau(181P)) and MRI scans were obtained in 399 subjects (109 CN, 192 aMCI, 98 AD). Structural Abnormality Index (STAND) scores, which reflect the degree of AD-like anatomic features on MRI, were computed for each subject.Results: We found no significant correlation between CSF biomarkers and cognitive scores in any of the 3 clinical groups individually. Conversely, STAND scores correlated with both Clinical Dementia Rating-sum of boxes and Mini-Mental State Examination in aMCI and AD (p