The SH2 and SH3 adapter Nck: a two-gene family and a linker between tyrosine kinases and multiple signaling networks.
The SH2 and SH3 adapter Nck: a two-gene family and a linker between tyrosine kinases and multiple signaling networks.
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DOI：
10.14670/hh-15.947
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发表时间：
2000-07
影响因子：
2
通讯作者：
W. Li;H. She
中科院分区：
文献类型：
--
作者：
W. Li;H. She
SH 2和SH 3衔接蛋白将细胞表面酪氨酸激酶连接到细胞内信号网络。例如，SH 3-SH 2-SH 3衔接子Grb 2将受体酪氨酸激酶连接到Ras途径。Nck由三个SH 3结构域和一个SH 2结构域组成，代表哺乳动物中的两个基因（α和β）家族。Nck alpha和Nck beta在相同的细胞中表达，并且似乎具有不同的信号传导特异性。研究表明，Nck在细胞有丝分裂和形态发生中起作用。前者使用Ras依赖性和Ras非依赖性途径。后者似乎与Cdc 42/Rac> PAK 1/WASp>肌动蛋白细胞骨架途径协调。了解Nckalpha和Nckbeta信号转导的特异性将为以前经常相互矛盾的观察结果提供答案。
SH2 and SH3 adapter proteins connect cell surface tyrosine kinases to intracellular signaling networks. For instance, the SH3-SH2-SH3 adapter Grb2 links receptor tyrosine kinases to the Ras pathway. Nck, composed of three SH3 domains and one SH2 domain, represents a two-gene (alpha and beta) family in mammals. Nckalpha and Nckbeta are expressed in the same cells and appear to have distinct signaling specificity. Studies show that Nck plays a role in cell mitogenesis and morphogenesis. The former uses Ras-dependent and Ras-independent pathways. The latter appears to coordinate with the Cdc42/Rac>PAK1/WASp>actin cytoskeleton pathway. Understanding the specificity of Nckalpha and Nckbeta signal transduction will provide answers for the previously often conflicting observations.