Salmonella enterica serotype Virchow:: epidemiology, resistance patterns and molecular characterisation of an invasive Salmonella serotype in Israel
Salmonella enterica serotype Virchow:: epidemiology, resistance patterns and molecular characterisation of an invasive Salmonella serotype in Israel
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DOI：
10.1111/j.1469-0691.2006.01466.x
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发表时间：
2006-10-01
影响因子：
14.2
通讯作者：
Cohen, D.
中科院分区：
文献类型：
--
作者：
Weinberger, M.;Solnik-Isaac, H.;Cohen, D.
这项研究概述了以色列肠道沙门氏菌血清型 Virchow 的独特流行病学。 1997年至2002年间，非伤寒沙门氏菌（NTS）的总发病率从69.3例/10万人下降到53.3例，但魏尔啸沙门氏菌的发病率却有所上升（从7.2例/10万人上升到9.1例）。自2000年以来，S. Virchow已成为排名第二的NTS分离株，分别占所有粪便和血液NTS分离株的17%和27%。 1岁以下婴儿因粪便隔离的发生率最高（92.8/10万）。 1 岁以下婴儿的血液分离发生率最高 (4.4/100 000)。只有 6% 的分离株对所有 10 种测试的抗生素药物敏感； 34% 对一种药物耐药，54% 对一到三种药物耐药，40% 对四到六种药物耐药。大部分测试菌株对萘啶酸（89％）、链霉素（56％）、四环素（43％）、甲氧苄氨嘧啶-磺胺甲恶唑（38％）和氯霉素（28％）具有耐药性，但对环丙沙星或头孢曲松没有耐药性。脉冲场凝胶电泳揭示了两个密切相关的簇，每个簇都包含一个主要的脉冲型。加上其入侵倾向，高度抗药性的魏氏沙门氏菌在以色列的发病率不断增加，令人真正担忧。未来的研究应重点关注魏尔啸病毒在食物链中的来源，以便制定有效的控制措施。
This study outlines the unique epidemiology of Salmonella enterica serotype Virchow in Israel. Between 1997 and 2002, the overall incidence of non-typhoid Salmonella enterica (NTS) decreased from 69.3 to 53.3 infections/100 000 population, but the incidence of S. Virchow increased (from 7.2 to 9.1 infections/100 000). Since 2000, S. Virchow has become the second-ranking NTS isolate, accounting for 17% and 27% of all stool and blood NTS isolates, respectively. Infants aged < 1 year had the highest incidence of isolation from stools (92.8/100 000). The incidence of isolation from blood was highest for infants aged < 1 year (4.4/100 000). Only 6% of isolates were susceptible to all ten antibiotic agents tested; 34% were resistant to one agent, 54% to one to three agents, and 40% to four to six agents. A high proportion of the tested isolates were resistant to nalidixic acid (89%), streptomycin (56%), tetracycline (43%), trimethoprim-sulphamethoxazole (38%) and chloramphenicol (28%), but none to ciprofloxacin or ceftriaxone. Pulsed-field gel electrophoresis revealed two closely related clusters, each containing a predominant pulsotype. Coupled with its invasive propensity, the increasing incidence of highly resistant S. Virchow in Israel is of real concern. Future research should focus on the sources of S. Virchow in the food chain in order to institute effective control measures.