Fructose malabsorption is associated with decreased plasma tryptophan
Fructose malabsorption is associated with decreased plasma tryptophan
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DOI：
10.1080/003655201300051135
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发表时间：
2001-04-01
影响因子：
1.9
通讯作者：
Fuchs, D
中科院分区：
文献类型：
--
作者：
Ledochowski, M;Widner, B;Fuchs, D
背景：果糖吸收不良的特点是无法有效吸收果糖。结果，果糖到达结肠，在那里被细菌分解成短脂肪酸、CO(2)、H(2)、CH(4) 和乳酸。腹胀、痉挛、渗透性腹泻和肠易激综合征的其他症状是约 50% 果糖吸收不良者的结果。最近发现果糖吸收不良与抑郁症的早期症状有关。因此，研究了果糖吸收不良是否与色氨酸代谢异常有关。方法：对 50 名患有胃肠道不适的成年人（16 名男性，34 名女性）在禁食过夜后口服 50 克果糖后测量呼吸氢浓度进行分析。根据呼吸 H(2) 浓度，将他们分为正常者或果糖吸收不良者。所有患者均填写了贝克抑郁量表调查问卷。采集血样进行血浆色氨酸和犬尿氨酸测量。结果：50 名个体中有 35 名 (70%) 检测到果糖吸收不良（呼吸 DeltaH(2) 产量 >20 ppm）。与果糖吸收正常的受试者相比，果糖吸收不良的受试者血浆色氨酸浓度显着降低，贝克抑郁量表得分显着较高。结论：果糖吸收不良与较低的色氨酸水平有关，色氨酸水平可能在抑郁症的发展中发挥作用。高肠道果糖浓度似乎会干扰 L-色氨酸代谢，并且可能会减少用于生物合成血清素（5-羟色胺）的色氨酸的可用性。对于有抑郁症状和色氨酸代谢紊乱的患者，应考虑果糖吸收不良。
Background: Fructose malabsorption is characterized by the inability to absorb fructose efficiently. As a consequence fructose reaches the colon where it is broken down by bacteria to short fatty acids, CO(2), H(2), CH(4) and lactic acid. Bloating, cramps, osmotic diarrhea and other symptoms of irritable bowel syndrome are the consequence and can be seen in about 50% of fructose malabsorbers. Recently it was found that fructose malabsorption was associated with early signs of depressive disorders. Therefore, it was investigated whether fructose malabsorption is associated with abnormal tryptophan metabolism. Methods: Fifty adults (16 men, 34 women) with gastrointestinal discomfort were analyzed by measuring breath hydrogen concentrations after an oral dose of 50 g fructose after an overnight fast. They were classified as normals or fructose malabsorbers according to their breath H(2) concentrations. All patients filled out a Beck depression inventory questionnaire. Blood samples were taken for plasma tryptophan and kynurenine measurements. Results: Fructose malabsorption (breath DeltaH(2) production >20 ppm) was detected in 35 of 50 individuals (70%). Subjects with fructose malabsorption showed significantly lower plasma tryptophan concentrations and significantly higher scores in the Beck depression inventory compared to those with normal fructose absorption. Conclusions: Fructose malabsorption is associated with lower tryptophan levels that may play a role in the development of depressive disorders. High intestinal fructose concentration seems to interfere with L-tryptophan metabolism, and it may reduce availability of tryptophan for the biosynthesis of serotonin (5-hydroxytryptamine). Fructose malabsorption should be considered in patients with symptoms of depression and disturbances of tryptophan metabolism.