PHYSIOLOGICAL INVESTIGATIONS INTO THE HEART FUNCTION OF ARTHROPODS - THE HEART OF PERIPLANETA-AMERICANA
PHYSIOLOGICAL INVESTIGATIONS INTO THE HEART FUNCTION OF ARTHROPODS - THE HEART OF PERIPLANETA-AMERICANA
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DOI：
10.1017/s0007485300025232
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发表时间：
1951-01-01
影响因子：
1.9
通讯作者：
KRIJGSMANBERGER, NE
中科院分区：
文献类型：
--
作者：
KRIJGSMAN, BJ;KRIJGSMANBERGER, NE
用咖啡因、洋地黄甙、乙酰胆碱、尼古丁和洛贝林灌流美洲大蠊离体心脏，表明该心脏的起搏器不同于脊椎动物心脏的“生肌中枢”。士的宁、吗啡和阿扑吗啡的作用证明了神经源性起搏器的存在。这个起搏器是用适当的电流刺激的。乙酰胆碱、烟碱、洛贝林和毛果芸香碱的作用，阿托品、乙酰胆碱和焦磷酸四乙酯的抑制作用显示协同作用。阿托品和焦磷酸四乙酯，像乙酰胆碱和箭毒一样，显示拮抗作用。这些结果证明神经源性起搏器具有胆碱能特性。肾上腺素刺激昆虫心脏，麦角胺抑制昆虫心脏。这表明昆虫的心脏也具有肾上腺素能特性。理论上，大多数节肢动物的心脏机制由具有肾上腺素能特性的神经性起搏器组成，由胆碱能加速神经控制。鱼藤酮抵消乙酰胆碱、焦磷酸四乙酯、尼古丁、洛贝林、毛果芸香碱和洋地黄苷对昆虫心脏的作用。
Perfusion of the isolated heart of Periplaneta americana with caffeine, digitalin, acetylcholine, nicotine and lobeline shows that the pacemaker of this heart differs from the "myogenic center" of the vertebrate heart. The action of strychnine, morphine and apomorphine gives evidence of the existence of a neurogenic pacemaker. This pacemaker is stimulated by suitable concns. of acetylcholine, nicotine, lobeline and pilocarpine; it is inhibited by atropine, Acetylcholine and tetraethyl pyrophosphate show a syntergistic action. Atropine and tetraethyl pyrophosphate, like acetycholine and curare, show an antagonistic action. These results prove that the neurogenic pacemaker possesses cholinergic properties. Adrenaline stimulates and ergotamine inhibits the insect heart. This suggests the insect heart also has adrenergic properties. It is theorized that the heart mechanism of most arthropods consists of a neurogenic pacemaker with adrenergic properties, controlled by a cholinergic accelerating nerve. Rotenone counteracts the action of acetylcholine, tetraethyl pyrophosphate, nicotine, lobeline, pilocarpine and digitalin on the insect heart.