The aging hippocampus: A multi-level analysis in the rat
The aging hippocampus: A multi-level analysis in the rat
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DOI：
10.1016/j.neuroscience.2006.01.040
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发表时间：
2006-01-01
期刊：
影响因子：
3.3
通讯作者：
Sutherland, R. J.
中科院分区：
文献类型：
--
作者：
Driscoll, I.;Howard, S. R.;Sutherland, R. J.
在当前的实验中，我们进行了多层次的分析，在年轻的成年人（3个月），中年（12个月），老年（24个月）Fisher 344 x Brown Norway杂交（FBNF 1）大鼠海马的年龄相关特征。我们研究了衰老，海马和记忆的行为，非侵入性的磁共振成像和光谱学相结合，并在同一大鼠死后的神经解剖措施之间的关系。衰老与海马依赖性记忆任务的功能缺陷相关，伴随着在体内（磁共振成像-海马体积）和死后（齿状回神经元密度和神经发生）观察到的结构改变。然而，神经元代谢的完整性，评估水平的N-乙酰天冬氨酸与磁共振波谱，保存。此外，我们的研究结果表明，神经发生（doublecortin）似乎是相关的两个性能缺陷对海马依赖的任务和海马体积减小。观察到的与年龄相关的变化模式与以前在人类中报道的非常相似，这表明FBNF 1大鼠是正常人类衰老的有用模型。(c)2006年IBRO。由爱思唯尔有限公司出版。保留所有权利。
In the current experiment we conducted a multi-level analysis of age-related characteristics in the hippocampus of young adult (3 months), middle-aged (12 months), and old (24 months) Fisher 344 x Brown Norway hybrid (FBNF1) rats. We examined the relationships between aging, hippocampus, and memory using a combination of behavioral, non-invasive magnetic resonance imaging and spectroscopy, and postmortem neuroanatomical measures in the same rats. Aging was associated with functional deficits on hippocampus-dependent memory tasks, accompanied by structural alterations observed both in vivo (magnetic resonance imaging-hippocampal volume) and postmortem (dentate gyrus neuronal density and neurogenesis). Neuronal metabolic integrity, assessed by levels of N-acetylaspartate with magnetic resonance spectroscopy, was however, preserved. Further, our results suggest that neurogenesis (doublecortin) seems to be related to both performance deficits on hippocampus-dependent tasks and hippocampal volume reduction. The observed pattern of age-related alterations closely resembles that previously reported in humans and suggests FBNF1 rats to be a useful model of normal human aging. (c) 2006 IBRO. Published by Elsevier Ltd. All rights reserved.