HPV post-infection microenvironment and cervical cancer
HPV post-infection microenvironment and cervical cancer
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HPV感染后微环境与宫颈癌
DOI：
10.1016/j.canlet.2020.10.034
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发表时间：
2021-01-28
期刊：
影响因子：
9.7
通讯作者：
Ma, Feng
中科院分区：
文献类型：
--
作者：
Yuan, Yi;Cai, Xushan;Ma, Feng
人乳头瘤病毒（HPV）是世界上最常见的性传播病毒。超过99%的宫颈癌病例与某些类型的HPV有关，称为高危类型。除了众所周知的转化特性之外，HPV感染的细胞积极指导局部环境并创造支持性的感染后微环境（PIM），这被认为是病毒持续存在、繁殖和恶性进展的关键因素。PIM通过病毒感染的细胞、免疫细胞和宿主基质以及它们的衍生组分（包括趋化因子、细胞因子、细胞外囊泡和代谢物）之间的复杂相互作用而启动和建立。在这篇综述中，我们总结了目前对PIM的这些关键成分、特征和作用的理解，并强调了靶向PIM作为改善宫颈癌治疗结果的潜在策略的前景。
Human papillomavirus (HPV) is the most common sexually transmitted virus worldwide. More than 99% of cervical cancer cases are associated with certain types of HPVs, termed high-risk types. In addition to the wellknown transformative properties, HPVs-infected cells actively instruct the local milieu and create a supportive post-infection microenvironment (PIM), which is becoming recognized as a key factor for the viral persistence, propagation, and malignant progression. The PIM is initiated and established via a complex interplay among virus-infected cells, immune cells, and host stroma, as well as their derived components including chemokines, cytokines, extracellular vesicles, and metabolites. In this review, we summarize the current understanding of these key components, characteristics, and effects of the PIM, and highlights the prospect of targeting the PIM as a potential strategy to improve therapeutic outcomes for cervical cancer.