Current challenges of gene therapy for prostate cancer.
Current challenges of gene therapy for prostate cancer.
复制标题
前列腺癌基因治疗当前面临的挑战。
作者：
Harrison Gs;Glode Lm
前列腺癌的基因治疗面临的障碍与其他癌症和非恶性过程遇到的障碍相似。最大的障碍是鉴定有效的递送系统，因为当大多数细胞表达引入的遗传物质时，许多动物模型和细胞培养系统已经显示出潜在的功效。早期前列腺癌易于引入基因载体，并且这种癌症的可预测的转移模式可能为基因治疗提供额外的优势。本文综述了基因载体和基因产物，以及正在进行的基因治疗试验，最近开始在前列腺癌。
Gene therapy for prostate cancer faces hurdles similar to those being encountered for other cancers and nonmalignant processes. The greatest obstacle is the identification of efficient delivery systems, since numerous animal models and cell culture systems have shown potential efficacy when most cells express the introduced genetic material. Early prostate cancers are easily accessible to gene vector introduction, and the predictable metastatic patterns of this cancer may offer additional advantages for gene therapy. This article reviews gene vectors and gene products, as well as ongoing trials of gene therapy that have recently begun in prostate cancer.
表达肿瘤抑制因子（C-CAM1）的重组腺病毒在雄激素非依赖性人前列腺癌治疗中的应用：临床前研究。
DOI：
--
发表时间：
1995
期刊：
Cancer research.
影响因子：
--
作者：
Kleinerman,DI;Zhang,WW;Lin,SH;Nguyen,TV;vonEschenbach,AC;Hsieh,JT
通讯作者：
Hsieh,JT
影响因子：
56.9
作者：
BREITMAN, ML;CLAPOFF, S;BERNSTEIN, A
通讯作者：
BERNSTEIN, A