Inside-out, outside-in, and inside-outside-in: G protein signaling in integrin-mediated cell adhesion, spreading, and retraction.
Inside-out, outside-in, and inside-outside-in: G protein signaling in integrin-mediated cell adhesion, spreading, and retraction.
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DOI：
10.1016/j.ceb.2012.08.011
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发表时间：
2012-10
影响因子：
7.5
通讯作者：
Du, Xiaoping
中科院分区：
文献类型：
--
作者：
Shen, Bo;Delaney, M. Keegan;Du, Xiaoping
细胞粘附受体的整合素家族介导双向信号传导：“由内而外”信号传导激活整合素的配体结合功能，“由外而内”信号传导介导配体与整合素结合诱导的细胞反应，从而导致细胞扩散、收缩、迁移和增殖。整合素信号传导需要异源三聚体 G 蛋白和单体小 G 蛋白。本综述重点关注 G 蛋白在整合素由外向内信号传导中的作用的最新进展。异源三聚体 G 蛋白亚基 Gα13 和整合素 β 亚基之间直接相互作用的发现揭示了整合素信号传导的新机制，也揭示了 G 蛋白偶联受体 (GPCR) 和整合素启动的信号传导途径之间的串扰。这种串扰可称为“内-外-内”信号传导，动态调节收缩性并极大地促进整合素由外向内信号传导
The integrin family of cell adhesion receptors mediates bi-directional signaling: “inside-out” signaling activates the ligand binding function of integrins and “outside-in” signaling mediates cellular responses induced by ligand binding to integrins leading to cell spreading, retraction, migration, and proliferation. Integrin signaling requires both heterotrimeric G proteins and monomeric small G proteins. This review focuses on recent development in the roles of G proteins in integrin outside-in signaling. The finding of direct interaction between the heterotrimeric G protein subunit Gα13 and integrin β subunits reveals a new mechanism for integrin signaling, and also uncovers a crosstalk between the signaling pathways initiated by G protein-coupled receptors (GPCRs) and integrins. This crosstalk, which may be referred to as “inside-outside-in” signaling, dynamically regulates contractility and greatly promotes integrin outside-in signaling
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DOI：
10.1083/jcb.200208043
发表时间：
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期刊：
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DOI：
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发表时间：
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期刊：
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