Small Molecule Epigenetic Modulators in Pure Chemical Cell Fate Conversion.
Small Molecule Epigenetic Modulators in Pure Chemical Cell Fate Conversion.
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纯化学细胞命运转换中的小分子表观遗传调节剂
DOI：
10.1155/2020/8890917
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发表时间：
2020
影响因子：
4.3
通讯作者：
Han YC
中科院分区：
文献类型：
--
作者：
Yuan ZD;Zhu WN;Liu KZ;Huang ZP;Han YC
Although innovative technologies for somatic cell reprogramming and transdifferentiation provide new strategies for the research of translational medicine, including disease modeling, drug screening, artificial organ development, and cell therapy, recipient safety remains a concern due to the use of exogenous transcription factors during induction. To resolve this problem, new induction approaches containing clinically applicable small molecules have been explored. Small molecule epigenetic modulators such as DNA methylation writer inhibitors, histone methylation writer inhibitors, histone acylation reader inhibitors, and histone acetylation eraser inhibitors could overcome epigenetic barriers during cell fate conversion. In the past few years, significant progress has been made in reprogramming and transdifferentiation of somatic cells with small molecule approaches. In the present review, we systematically discuss recent achievements of pure chemical reprogramming and transdifferentiation.
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