Biologically Active Polymersomes from Amphiphilic Glycopeptides
Biologically Active Polymersomes from Amphiphilic Glycopeptides
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DOI：
10.1021/ja209676p
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发表时间：
2012-01-11
影响因子：
15
通讯作者：
Heise, Andreas
中科院分区：
文献类型：
--
作者：
Huang, Jin;Bonduelle, Colin;Heise, Andreas
以丙叉甘氨酸(PG)N-羧酸酐和L-谷氨酸苄酯为原料，通过顺序开环聚合制备了不同嵌段长度比的多肽嵌段共聚物。聚(PG)嵌段的糖基化是通过叠氮半乳糖的惠氏环加成“Click”反应得到的。根据嵌段长度比和纳米沉淀条件，采用纳米沉淀法对所有共聚物进行自组装，得到球形和蠕虫状的胶束以及聚合体。选择性凝集素结合实验证明，这些结构在聚合体外壳中显示出生物活性的半乳糖单元。
Polypeptide block copolymers with different block length ratios were obtained by sequential ring-opening polymerization of benzyl-L-glutamate and propargylglycine (PG) N-carboxyanhydrides. Glycosylation of the poly(PG) block was obtained by Huisgens cycloaddition "click" reaction using azide-functionalized galactose. All copolymers were self-assembled using the nanoprecipitation method to obtain spherical and wormlike micelles as well as polymersomes depending on the block length ratio and the nanoprecipitation conditions. These structures display bioactive galactose units in the polymersome shell, as proven by selective lectin binding experiments.