Keeping neural progenitor cells on a short leash during Drosophila neurogenesis.
Keeping neural progenitor cells on a short leash during Drosophila neurogenesis.
复制标题
在果蝇神经发生过程中对神经祖细胞进行严格控制。
DOI：
10.1016/j.conb.2010.09.005
复制
发表时间：
2011
影响因子：
5.7
通讯作者：
Lee,Cheng-Yu
中科院分区：
文献类型：
--
作者：
Weng,Mo;Lee,Cheng-Yu
干细胞和祖细胞的发育潜力必须在功能上加以区分，以确保产生不同的细胞类型，同时在生物体的整个生命周期中维持干细胞库。与干细胞相反，祖细胞具有有限的发育潜力，使它们只能产生有限数量的有丝分裂后后代。不能建立或维持受限制的祖细胞潜能会扰乱组织发育和体内平衡，并可能导致肿瘤发生。最近的研究使用发育中的果蝇幼虫脑提供了分子洞察力的发育潜力是如何限制在神经祖细胞。
The developmental potential of stem cells and progenitor cells must be functionally distinguished to ensure the generation of diverse cell types while maintaining the stem cell pool throughout the lifetime of an organism. In contrast to stem cells, progenitor cells possess restricted developmental potential, allowing them to give rise to only a limited number of post-mitotic progeny. Failure to establish or maintain restricted progenitor cell potential can perturb tissue development and homeostasis, and probably contributes to tumor initiation. Recent studies using the developing fruit fly Drosophila larval brain have provided molecular insight into how the developmental potential is restricted in neural progenitor cells.