Barriers to adolescents' participation in HIV biomedical prevention research.
Barriers to adolescents' participation in HIV biomedical prevention research.
复制标题
DOI：
10.1097/qai.0b013e3181e1e2c0
复制
发表时间：
2010-07
期刊：
影响因子：
--
通讯作者：
Sales JM
中科院分区：
文献类型：
--
作者：
DiClemente RJ;Ruiz MS;Sales JM
将青少年纳入艾滋病毒预防临床研究有可能提高目前对生物医学预防技术在艾滋病毒感染风险不断增加的年轻人群中的安全性和有效性的了解。然而，有显着的个人，业务和社区层面的障碍，让青少年参与临床预防试验。本文确定并解决个人，业务和社区层面的障碍，青少年参与艾滋病毒的生物医学预防研究。在论文中确定和解决的障碍包括：（1）对临床预防研究的理解不足，（2）自我介绍偏见，（3）围绕父母同意的问题，（4）进入临床试验，（5）对研究的不信任，以及（6）与参与临床试验相关的耻辱。青少年已经成功地从事预防研究的方案的例子突出显示，从这些方案中吸取的教训表明，建立与社区的主要利益相关者的合作是必不可少的进行生物医学研究与弱势群体，包括青少年。鉴于了解年轻人对新生物医学预防技术的反应、可接受性和利用的重要性，研究人员必须承认并解决这些障碍，以提高青少年对艾滋病毒生物医学预防研究的参与和保留。
The inclusion of adolescents in HIV prevention clinical research has the potential to improve the current understanding of the safety and efficacy of biomedical prevention technologies in younger populations that are at increasing risk of HIV infection. However, there are significant individual, operational, and community-level barriers to engaging adolescents in clinical prevention trials. This paper identifies and addresses individual, operational, and community-level barriers to adolescents' participation in HIV biomedical prevention research. Barriers identified and addressed in the paper include: (1) insufficient understanding of clinic prevention research, (2) self-presentation bias, (3) issues surrounding parental consent, (4) access to clinical trials, (5) mistrust of research, and (6) stigma associated with participation in clinical trials. Examples of programs where adolescents have been successfully engaged in prevention research are highlighted and the lessons learned from these programs indicate that establishing collaborations with key stakeholders in the community are essential for conducting biomedical research with vulnerable populations, including adolescents. Given the importance of understanding young peoples' reactions to, acceptability, and utilization of new biomedical prevention technologies it is imperative that researchers acknowledge and address these barriers to enhance adolescents' participation and retention in HIV biomedical prevention research.