Trends in stomach cancer mortality in relation to living conditions in childhood. A study among cohorts born between 1860 and 1939 in seven European countries
Trends in stomach cancer mortality in relation to living conditions in childhood. A study among cohorts born between 1860 and 1939 in seven European countries
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DOI：
10.1016/j.ejca.2006.04.020
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发表时间：
2006-12-01
影响因子：
8.4
通讯作者：
Mackenbach, J. P.
中科院分区：
文献类型：
--
作者：
Amiri, M.;Kunst, A. E.;Mackenbach, J. P.
目的：评估胃癌死亡率的长期趋势是否与婴儿死亡率（IMR）或国内生产总值（GDP）的趋势相关。方法：对欧洲7个国家的资料进行分析。我们使用泊松回归来描述1865-1939年出生队列的死亡率趋势，并使用相关系数来确定与IMR/GDP的关系。结果：在出生队列中观察到胃癌死亡率的巨大差异。在每个国家，这些队列差异与出生时的IMR/GDP水平密切相关。然而，在晚年生活条件的测量中观察到更强的关联。在国家之间的比较中，胃癌死亡率与国家的IMR/GDP水平并不一致。结论：儿童时期的一般生活条件似乎对胃癌死亡率的长期趋势没有主要影响。死亡率的下降可能与更具体的因素有关，如幽门螺杆菌患病率的下降。(c) 2006 Elsevier Ltd.版权所有。
Aim: To assess whether secular trends in stomach cancer mortality were correlated with trends in infant mortality rate (IMR) or gross domestic product (GDP).Methods: Data from seven European countries were analyzed. We used Poisson regression to describe mortality trends among birth cohorts of 1865-1939 and correlation coefficients to determine associations with IMR/GDP.Results: Large differences were observed between birth cohorts in mortality from stomach cancer. In each country, these cohort differences were closely related to IMR/GDP levels at birth time. However, stronger associations were observed with measures of living conditions during later life. In comparisons between countries, stomach cancer mortality rates were not consistently related to national levels of IMR/GDP.Conclusion: General living conditions in childhood do not seem to have had a predominant effect on secular trends in stomach cancer mortality. The mortality decline is likely to be related to more 1specific factors, such as declining Helicobacter pylori prevalence. (c) 2006 Elsevier Ltd. All rights reserved.