Cellular senescence in aging primates
Cellular senescence in aging primates
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DOI：
10.1126/science.1122446
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发表时间：
2006-03-03
期刊：
影响因子：
56.9
通讯作者：
Sedivy, JM
中科院分区：
文献类型：
--
作者：
Herbig, U;Ferreira, M;Sedivy, JM
生物体衰老的特点是所有器官系统的功能逐渐衰退。培养中的哺乳动物体细胞显示出有限的增殖寿命，在寿命结束时它们会经历不可逆的细胞周期停滞，称为复制衰老。细胞衰老是否会导致机体衰老一直存在争议。我们研究了端粒功能障碍，这是最近发现的细胞衰老的生物标志物，发现衰老狒狒皮肤中衰老成纤维细胞的数量呈指数增加，达到高龄个体所有细胞的 15% 以上。此外，相同的细胞含有激活的共济失调毛细血管扩张突变激酶和异染色质化的细胞核，证实了它们的衰老状态。
The aging of organisms is characterized by a gradual functional decline of all organ systems. Mammalian somatic cells in culture display a limited proliferative life span, at the end of which they undergo an irreversible cell cycle arrest known as replicative senescence. Whether cellular senescence contributes to organismal aging has been controversial. We investigated telomere dysfunction, a recently discovered biomarker of cellular senescence, and found that the number of senescent fibroblasts increases exponentially in the skin of aging baboons, reaching >15% of all cells in very old individuals. In addition, the same cells contain activated ataxia-telangiectasia mutated kinase and heterochromatinized nuclei, confirming their senescent status.