THE INSULIN-RESISTANCE SYNDROME IN SMOKERS IS RELATED TO SMOKING-HABITS
THE INSULIN-RESISTANCE SYNDROME IN SMOKERS IS RELATED TO SMOKING-HABITS
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DOI：
10.1161/01.atv.14.12.1946
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发表时间：
1994-12-01
期刊：
影响因子：
--
通讯作者：
SMITH, U
中科院分区：
文献类型：
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作者：
ELIASSON, B;ATTVALL, S;SMITH, U
采用正葡萄糖钳夹技术对57名中年男性吸烟者的胰岛素抵抗程度进行定量分析，研究吸烟习惯、胰岛素抵抗和心血管疾病相关危险因素之间的关系。吸烟习惯与胰岛素抵抗程度相关，因此与胰岛素抵抗综合征的各种表现相关，包括胰岛素水平、高密度脂蛋白胆固醇、甘油三酯和纤溶酶原激活物抑制剂-1（派-1）活性。吸烟习惯，独立于胰岛素抵抗的程度，也与总胆固醇和低密度脂蛋白胆固醇以及甘油三酯的水平有关。考虑年龄、瘦体重、体脂、体重指数、腰臀比和饮酒量的逐步回归分析显示，只有吸烟习惯和体脂百分比与胰岛素抵抗程度独立相关。这项研究表明，胰岛素抵抗和胰岛素抵抗综合征是重要的，但不是唯一的贡献者，以强大的风险概况，心血管疾病的中年男子谁吸烟。
The relationship between smoking habits, insulin resistance, and related risk factors for cardiovascular disease was examined in 57 middle-aged male smokers whose degree of insulin resistance was quantified by using the euglycemic clamp technique. Smoking habits correlated with degree of insulin resistance and consequently with various manifestations of the insulin resistance syndrome including levels of insulin, high-density lipoprotein cholesterol, triglycerides, and plasminogen activator inhibitor-1 (PAI-1) activity. Smoking habits, independent of degree of insulin resistance, were also related to levels of total cholesterol and low-density lipoprotein cholesterol as well as triglycerides. Stepwise regression analyses considering the effects of age, lean body mass, body fat, body mass index, waist/hip ratio, and alcohol consumption showed that only smoking habits and percent body fat were independently related to degree of insulin resistance. This study shows that insulin resistance and the insulin resistance syndrome are important but not unique contributors to the strong risk profile for cardiovascular disease in middle-aged men who smoke.