COMPARATIVE EPIDEMIOLOGY OF PEMPHIGUS IN TUNISIA AND FRANCE - UNUSUAL INCIDENCE OF PEMPHIGUS FOLIACEUS IN YOUNG TUNISIAN WOMEN
COMPARATIVE EPIDEMIOLOGY OF PEMPHIGUS IN TUNISIA AND FRANCE - UNUSUAL INCIDENCE OF PEMPHIGUS FOLIACEUS IN YOUNG TUNISIAN WOMEN
复制标题
DOI：
10.1111/1523-1747.ep12612836
复制
发表时间：
1995-02-01
影响因子：
6.5
通讯作者：
KAMOUN, MR
中科院分区：
文献类型：
--
作者：
BASTUJIGARIN, S;SOUISSI, R;KAMOUN, MR
最近的研究表明，在突尼斯，叶状天疱疮在年轻女性中比预期的更常见。为了证实这些发现，我们比较了整个突尼斯和法国大部分地区天疱疮的发病率。回顾性分析我院皮肤科和病理实验室6年来发现的新发天疱疮病例，并根据病理情况将其分类为寻常型天疱疮或叶状天疱疮。在法国，发病率为每年每百万人1.7例（95%置信区间为1.4至2.1）。寻常型天疱疮占所有病例的73%，发病率随年龄增长而增加，男女性别比为1.2。突尼斯的发病率明显高于法国：每年每百万人6.7例（95%可信区间为5.8至7.7）；叶状天疱疮发病率较高（61%），男女性别比为4.1，年轻女性发病率较高。在25至34岁的女性中，叶性天疱疮的发病率为每年每百万人15.5例，在一些农村地区甚至更高。家庭成员和新生儿中未发现病例，儿童期仅有1例。因此，我们证实了突尼斯天疱疮的流行病学是不寻常的。生活在农村地区的年轻人中，叶状天疱疮的高发率让人想起巴西天疱疮。然而，与巴西天疱疮相比，在遗传相关的家庭成员和儿童中没有病例，妇女占多数。
Recent studies have suggested that in Tunisia, pemphigus foliaceus is more frequent in young women than expected. To confirm these findings, we compared the incidence rates of pemphigus in Tunisia as a whole and in a large area of France. New cases of pemphigus were detected retrospectively from dermatology departments and pathology laboratories over a 6-year period and classified as pemphigus vulgaris or foliaceus according to the pathology. In France, the incidence rate was 1.7 cases per million per year (95% confidence interval 1.4 to 2.1). Pemphigus vulgaris accounted for 73% of all cases, incidence increased with age, and the female-to-male sex ratio was 1.2. The incidence rate was significantly higher in Tunisia than in France: 6.7 cases per million per year (95% confidence interval 5.8 to 7.7); pemphigus foliaceus was more frequent (61%), the female-to-male sex ratio was 4.1, and the incidence rate was higher in young women. The incidence rate was 15.5 cases per million per year for pemphigus foliaceus among women aged 25 to 34 years and was even higher in some rural areas. No case was observed among household members or in neonates, and only one case occurred in childhood. Thus, we confirmed that the epidemiology of pemphigus in Tunisia is unusual. High rates of pemphigus foliaceus among young people living in rural areas are reminiscent of Brazilian pemphigus. However, the absence of cases among genetically related household members and during childhood, and the large predominance of women, contrast with Brazilian pemphigus.