Mitochondrial reactive oxygen species at the heart of the matter: new therapeutic approaches for cardiovascular diseases.
Mitochondrial reactive oxygen species at the heart of the matter: new therapeutic approaches for cardiovascular diseases.
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DOI：
10.1161/circresaha.116.305432
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发表时间：
2015-05-22
影响因子：
20.1
通讯作者：
Mochly-Rosen D
中科院分区：
文献类型：
--
作者：
Kornfeld OS;Hwang S;Disatnik MH;Chen CH;Qvit N;Mochly-Rosen D
活性氧（ROS）与多种年龄相关性疾病（包括多种心血管疾病）有关。然而，ROS清除剂（抗氧化剂）在临床上的应用并不成功。这些抗氧化剂显著降低细胞ROS的总水平，包括参与生理信号传导的ROS。在这篇综述中，我们挑战传统的抗氧化治疗方法，直接靶向ROS与新的方法，改善线粒体功能，更有效地治疗心血管疾病。
Reactive oxygen species (ROS) have been implicated in a variety of age-related diseases including multiple cardiovascular disorders. However, translation of ROS scavengers (anti-oxidants) into the clinic has not been successful. These anti-oxidants grossly reduce total levels of cellular ROS including ROS that participate in physiological signaling. In this review, we challenge the traditional anti-oxidant therapeutic approach that targets ROS directly with novel approaches that improve mitochondrial functions to more effectively treat cardiovascular diseases.