Perturbations in the gene regulatory pathways controlling mitochondrial energy production in the failing heart.
Perturbations in the gene regulatory pathways controlling mitochondrial energy production in the failing heart.
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DOI：
10.1016/j.bbamcr.2012.08.015
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发表时间：
2013-04
影响因子：
5.1
通讯作者：
Kelly, Daniel P.
中科院分区：
文献类型：
--
作者：
Aubert, Gregory;Vega, Rick B.;Kelly, Daniel P.
关键词：
心脏是一个杂食性器官，需要不断的能量生产来满足其功能需求。在成人心脏中，ATP的产生主要通过线粒体脂肪酸和葡萄糖氧化发生。心脏必须不断调整其能量产生，以响应不同生理和病理生理条件下基质供应和工作需求的变化。心肌细胞通过由过氧化物酶体增殖物激活受体γ共激活因子-1（PGC-1）家族成员协调的复杂转录调控网络维持高水平的线粒体ATP产生。越来越多的证据表明，在心脏肥大的发展过程中和衰竭的心脏中，这个网络的活性，包括PGC-1，发生了改变。这篇综述总结了我们目前对心力衰竭发生过程中基因调控通路的扰动的认识。对这种调节回路在调节心脏能量代谢中的作用的认识可能会揭示针对预示心力衰竭的代谢紊乱的新的治疗靶点。
The heart is an omnivore organ that requires constant energy production to match its functional demands. In the adult heart, ATP production occurs mainly through mitochondrial fatty acid and glucose oxidation. The heart must constantly adapt its energy production in response to changes in substrate supply and work demands across diverse physiologic and pathophysiologic conditions. The cardiac myocyte maintains a high level of mitochondrial ATP production through a complex transcriptional regulatory network that is orchestrated by the members of the peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family. There is increasing evidence that during the development of cardiac hypertrophy and in the failing heart, the activity of this network, including PGC-1, is altered. This review summarizes our current understanding of the perturbations in the gene regulatory pathways that occur during the development of heart failure. An appreciation of the role this regulatory circuitry serves in the regulation of cardiac energy metabolism may unveil novel therapeutic targets aimed at the metabolic disturbances that presage heart failure.
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DOI：
10.1073/pnas.0808207105
发表时间：
2008-11-04
影响因子：
11.1
作者：
Coste, Agnes;Louet, Jean-Francois;Auwerx, Johan
通讯作者：
Auwerx, Johan
DOI：
10.1073/pnas.0603615103
发表时间：
2006-06-27
影响因子：
11.1
作者：
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通讯作者：
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DOI：
10.1073/pnas.0337639100
发表时间：
2003-02-18
影响因子：
11.1
作者：
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通讯作者：
Olson, EN
影响因子：
5.3
作者：
Chang, SR;McKinsey, TA;Olson, EN
通讯作者：
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影响因子：
29
作者：
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