Stable Polymorphs Crystallized Directly under Thermodynamic Control in Three-Dimensional Nanoconfinement: A Generic Methodology
Stable Polymorphs Crystallized Directly under Thermodynamic Control in Three-Dimensional Nanoconfinement: A Generic Methodology
复制标题
三维纳米限制中热力学控制下直接结晶的稳定多晶型物：通用方法
DOI：
10.1021/cg101200f
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发表时间：
2011
影响因子：
3.8
通讯作者：
Nicholson C
中科院分区：
文献类型：
--
作者：
Nicholson C
Thermodynamic control of crystallization has been achieved to produce stable polymorphs directly by using three-dimensional (3D) nanoconfinement in microemulsions. The theoretical basis for thermodynamic control of crystallization using 3D nanoconfinement is outlined. Our approach leap-frogs the usual metastable polymorph pathway because crystallization becomes governed by the ability to form stable nuclei, rather than critical nuclei. The generality of this approach is demonstrated by crystallizing the stable polymorph of three “problem” compounds from microemulsions under conditions yielding metastable forms in bulk solution. The polymorphic compounds are mefenamic acid (2-[(2,3-(dimethylphenyl)amino] benzoic acid), glycine (aminoethanoic acid), and the highly polymorphic 5-methyl-2-[(2-nitrophenyl) amino]-3-thiophenecarbonitrile, commonly known as ROY because of its red, orange, and yellow polymorphs. Application of this methodology should prevent another Ritonavir-type disaster, whereby a marketed drug transforms into a more stable form, reducing its bioavailability and effectiveness. The lowest energy nuclei selectively grow in our approach. Consequently, this also provides a generic method for producing higher crystallinity materials, which may prove beneficial for crystallizing proteins and inorganic nanocrystals.
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使用转相乳液来显示加热和冷却时的界面结晶现象。
影响因子：
15
作者：
C. Nicholson;S. J. Cooper;C. Marcellin;M. Jamieson
通讯作者：
M. Jamieson
影响因子：
1.5
作者：
Cesur, S.;Gokbel, S.
通讯作者：
Gokbel, S.
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DOI：
--
发表时间：
2000
期刊：
影响因子：
--
作者：
J. Yano;H. Füredi;A. Wachtel;N. Garti
通讯作者：
N. Garti
影响因子：
4.4
作者：
Reguera, D;Bowles, RK;Reiss, H
通讯作者：
Reiss, H
微乳液结晶——一种制备阿斯巴甜新晶型的新方法
DOI：
--
发表时间：
1999
期刊：
影响因子：
--
作者：
H. Füredi;N. Garti;A. Kamyshny
通讯作者：
A. Kamyshny