The c-Myb functions as a downstream target of PDGF-mediated survival signal in vascular smooth muscle cells
The c-Myb functions as a downstream target of PDGF-mediated survival signal in vascular smooth muscle cells
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c-Myb 是血管平滑肌细胞中 PDGF 介导的生存信号的下游靶标。
DOI：
10.1016/j.bbrc.2007.06.078
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发表时间：
2007-08-24
影响因子：
3.1
通讯作者：
Mo, Xianming
中科院分区：
文献类型：
--
作者：
Chen, Yilan;Xu, Hong;Mo, Xianming
血管平滑肌细胞凋亡是动脉粥样硬化的主要病理特征之一。血小板衍生生长因子（PDGF）途径已显示在VSMC中提供存活信号，并且PDGF受体也在动脉粥样硬化斑块中包含的VSMC中高度表达。然而，PDGF信号传导的下游靶点尚不清楚。在目前的研究中，我们表明，PDGF信号刺激人动脉VSMCs中c-Myb的蛋白表达。抑制VSMCs中的c-Myb功能增强PDGF处理的VSMCs中的凋亡。我们的数据表明，c-Myb作为PDGF存活通路的下游靶点发挥作用，并表明c-Myb在成人VSMC存活中起重要作用。(C)2007爱思唯尔公司All rights reserved.
Apoptosis of vascular smooth muscle cell (VSMC) is one of the major pathologic features in atherosclerosis. The platelet-derived growth factor (PDGF) pathway has been shown to provide survival signals in VSMCs and PDGF receptors are also highly expressed in VSMCs contained in the plaques of atherosclerosis. However, the downstream targets of PDGF signaling are unclear. In the current study, we show that PDGF signals stimulate the protein expression of c-Myb in human arterial VSMCs. Inhibition of c-Myb function in VSMCs enhanced apoptosis in PDGF treated VSMCs. Our data suggest that c-Myb functions as a downstream target of the PDGF survival pathway and suggest that c-Myb plays an essential role in adult VSMC survival. (C) 2007 Elsevier Inc. All rights reserved.