EVIDENCE FOR DOPAMINE AS AN INHIBITOR OF VASOPROTEIN RELEASE IN MAN
EVIDENCE FOR DOPAMINE AS AN INHIBITOR OF VASOPROTEIN RELEASE IN MAN
复制标题
多巴胺作为人类血管蛋白释放抑制剂的证据
作者：
S. Lightman;M. Forsling
多巴胺对抗利尿激素释放的影响是通过输注左旋多巴来研究的，左旋多巴是一种穿过血脑屏障的多巴胺前体。左旋多巴抑制静息状态下的抗利尿激素水平，并抑制由头向上倾斜产生的抗利尿激素的升高。卡比多巴是一种脱羧酶抑制剂，不能穿过血脑屏障，可阻断左旋多巴的作用。这些结果表明，多巴胺抑制抗利尿激素的释放，要么是通过垂体水平的作用，要么是通过下丘脑正中隆起的作用。
The effect of dopamine on vasopressin release was studied by the infusion of L‐Dopa, a dopamine precursor that crosses the blood‐brain barrier. L‐Dopa suppressed resting levels of vasopressin and inhibited the rise of vasopressin produced by head‐up tilt. Carbidopa, a decarboxylase inhibitor that does not cross the blood‐brain barrier blocked the action of L‐Dopa. These results suggest that dopamine inhibits the release of vasopressin, either by an action at pituitary level or at the median eminence of the hypothalamus.