Cationic Gold(I)-Catalyzed Intramolecular Cyclization of γ-Hydroxyalkynones into 3(2H)-Furanones
Cationic Gold(I)-Catalyzed Intramolecular Cyclization of γ-Hydroxyalkynones into 3(2H)-Furanones
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DOI：
10.1021/jo100048j
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发表时间：
2010-03-19
影响因子：
3.6
通讯作者：
Akai, Shuji
中科院分区：
文献类型：
--
作者：
Egi, Masahiro;Azechi, Kenji;Akai, Shuji
(p-CF3C6H4)(3)PAuCl 和 AgOTf 的组合可产生强大的催化剂，用于在温和条件下容易获得的 γ-羟基炔酮的分子内环化。取代的3(2H)-呋喃酮的产率为55-94%。该方法也适用于2,3-二氢-4H-吡喃-4-酮的制备。
The combination of (p-CF3C6H4)(3)PAuCl and AgOTf generates a powerful catalyst for the intramolecular cyclizations of readily available gamma-hydroxyalkynones under mild conditions. The Substituted 3(2H)-furanones are obtained in 55-94% yields. This method is also applicable to the preparation of 2,3-dihydro-4H-pyran-4-ones.