Striatal activation during acquisition of a cognitive skill
Striatal activation during acquisition of a cognitive skill
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DOI：
10.1037/0894-4105.13.4.564
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发表时间：
1999-10-01
期刊：
影响因子：
2.4
通讯作者：
Gabrieli, JDE
中科院分区：
文献类型：
--
作者：
Poldrack, RA;Prabhakaran, V;Gabrieli, JDE
纹状体被认为在获得广泛的运动，感知和认知技能中起着至关重要的作用，但神经影像学尚未证明纹状体在非运动技能学习过程中的激活。在参与者学习概率分类的同时进行功能性磁共振成像，概率分类是一项认知任务，在学习早期依赖于程序记忆，在学习后期依赖于陈述性记忆。与感知运动控制任务相比，在概率分类过程中，多个大脑区域都很活跃，包括双侧额叶皮质、枕叶皮质和纹状体中的右尾状核。左侧海马在概率分类过程中双边活动比在控制任务，这海马失活的时间过程中的预期参与内侧颞叶结构的基础上的健忘症患者的行为研究。研究结果提供了初步的证据额纹状体系统在正常的认知技能学习的作用。
The striatum is thought to play an essential role in the acquisition of a wide range of motor, perceptual, and cognitive skills, but neuroimaging has not yet demonstrated striatal activation during nonmotor skill learning. Functional magnetic resonance imaging was performed while participants learned probabilistic classification, a cognitive task known to rely on procedural memory early in learning and declarative memory later in learning. Multiple brain regions were active during probabilistic classification compared with a perceptual-motor control task, including bilateral frontal cortices, occipital cortex, and the right caudate nucleus in the striatum. The left hippocampus was less active bilaterally during probabilistic classification than during the control task, and the time course of this hippocampal deactivation paralleled the expected involvement of medial temporal structures based on behavioral studies of amnesic patients. Findings provide initial evidence for the role of frontostriatal systems in normal cognitive skill learning.