Ciprofibrate therapy improves endothelial function and reduces postprandial lipemia and oxidative stress in type 2 diabetes mellitus
Ciprofibrate therapy improves endothelial function and reduces postprandial lipemia and oxidative stress in type 2 diabetes mellitus
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DOI：
10.1161/01.cir.101.15.1773
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发表时间：
2000-04-18
期刊：
影响因子：
37.8
通讯作者：
Rees, A
中科院分区：
文献类型：
--
作者：
Evans, M;Anderson, RA;Rees, A
背景-餐后高脂血症（PPL）是动脉粥样硬化形成的一个因素，涉及内皮功能障碍和氧化应激增强。我们研究了环丙贝特治疗对2型糖尿病的这些参数的影响。方法和结果20例患者进入了一个为期3个月的，双盲，安慰剂对照研究。每例受试者在空腹和脂肪餐后、基线和治疗3个月后进行研究。在餐后8小时内测量血糖和血脂谱。在空腹和餐后4小时测量内皮功能（血流介导的内皮依赖性血管舒张[FMD]）和氧化应激（电子顺磁共振光谱）。基线时，两组显示相似的PPL和内皮功能恶化。服用环丙贝特后，空腹和餐后FMD值显著升高（从3.8+/-1.8%和1.8+/-1.3%增至4.8+/-1.1%和3.4+/-1.1%; P
Background-Exaggerated postprandial lipemia (PPL) is a factor in atherogenesis, involving endothelial dysfunction and enhanced oxidative stress. We examined the effect of ciprofibrate therapy on these parameters in type 2 diabetes mellitus.Methods and Results-Twenty patients entered a 3-month, double-blind, placebo-controlled study. Each subject was studied fasting and after a fatty meal, at baseline, and after 3 months of treatment. Glucose and lipid profiles were measured over an 8-hour postprandial period. Endothelial function (flow-mediated endothelium-dependent vasodilatation [FMD]) and oxidative stress (electron paramagnetic resonance spectroscopy) were measured after fasting and 4 hours postprandially, At baseline, both groups exhibited similar PPL and deterioration in endothelial function. After ciprofibrate, fasting and postprandial FMD values were significantly higher (from 3.8+/-1.8% and 1.8+/-1.3% to 4.8+/-1.1% and 3.4+/-1.1%; P