Changes in brain activation during the acquisition of a new bimanual coordination task
Changes in brain activation during the acquisition of a new bimanual coordination task
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DOI：
10.1016/j.neuropsychologia.2003.12.010
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发表时间：
2004-01-01
期刊：
影响因子：
2.6
通讯作者：
Swinnen, SP
中科院分区：
文献类型：
--
作者：
Debaere, F;Wenderoth, N;Swinnen, SP
运动技能的获得与自动化的发展相关，并引起大脑的神经可塑性变化。本研究利用功能磁共振成像（fMRI）追踪了在获得新的复杂双手技能过程中与学习相关的激活变化，这需要四肢之间存在困难的时空关系，即相位偏移为 90 度的双手的周期性屈曲-伸展运动。在初始学习期间和建立协调模式后对受试者进行扫描。动作的运动学被准确地记录下来，表明新技能已经掌握得很好。在右侧背外侧前额叶皮层 (DLPFC)、右侧前运动部、双侧上顶叶皮层和左侧小脑小叶 VI 中发现了与学习相关的激活减少。相反，在双侧初级运动皮层、双侧颞上回、双侧扣带回运动皮层 (CMC)、左前运动皮层、小脑齿状核/小叶 III/IV/小腿 I、壳核/苍白球和丘脑中观察到与学习相关的激活增加。因此，双手技能学习与皮质-皮质下区域之间的激活变化相关，这为在学习的早期和高级阶段优先参与的不同皮质-皮质下回路的存在提供了进一步的证据。观察到的激活变化解释了从高度集中注意力的任务表现（涉及感觉信息的处理和纠正行动计划）到基于记忆表示和前向控制的自动表现的转变。 (C) 2004 Elsevier Ltd. 保留所有权利。
Motor skill acquisition is associated with the development of automaticity and induces neuroplastic changes in the brain. Using functional magnetic resonance imaging (fMRI), the present study traced leaming-related activation changes during the acquisition of a new complex bimanual skill, requiring a difficult spatio-temporal relationship between the limbs, i.e., cyclical flexion-extension movements of both hands with a phase offset of 90degrees. Subjects were scanned during initial learning and after the coordination pattern was established. Kinematics of the movements were accurately registered and showed that the new skill was acquired well. Learning-related decreases in activation were found in right dorsolateral prefrontal cortex (DLPFC), right premotor, bilateral superior parietal cortex, and left cerebellar lobule VI. Conversely, learning-related increases in activation were observed in bilateral primary motor cortex, bilateral superior temporal gyrus, bilateral cingulate motor cortex (CMC), left premotor cortex, cerebellar dentate nuclei/lobule III/IV/Crus I, putamen/globus pallidus and thalamus. Accordingly, bimanual skill learning was associated with a shift in activation among cortico-subcortical regions, providing further evidence for the existence of differential cortico-subcortical circuits preferentially involved during the early and advanced stages of learning. The observed activation changes account for the transition from highly attention-demanding task performance, involving processing of sensory information and corrective action planning, to automatic performance based on memory representations and forward control. (C) 2004 Elsevier Ltd. All rights reserved.