The ins and outs of meaning: Behavioral and neuroanatomical dissociation of semantically-driven word retrieval and multimodal semantic recognition in aphasia.
The ins and outs of meaning: Behavioral and neuroanatomical dissociation of semantically-driven word retrieval and multimodal semantic recognition in aphasia.
复制标题
DOI：
10.1016/j.neuropsychologia.2015.02.014
复制
发表时间：
2015-09
期刊：
影响因子：
2.6
通讯作者：
Schwartz MF
中科院分区：
文献类型：
--
作者：
Mirman D;Zhang Y;Wang Z;Coslett HB;Schwartz MF
关于语言处理架构的理论在语言和非语言理解是否共享功能和神经基础以及理解中的意义提取如何与使用意义驱动语言产生的能力相关方面存在差异。我们（重新）评估99名慢性失语症患者的17项认知语言性能指标的数据，使用因子分析建立功能组件和基于支持向量回归的病变-症状映射，以确定这些功能组件上的缺陷的神经相关性。这一结果与我们先前的研究结果高度一致：语义错误的产生在行为上和神经解剖学上不同于言语和非言语理解。语义错误与左ATL损伤最密切相关，而语言和非语言语义识别测试的缺陷与多个神经束汇合处额叶深层白色物质损伤最密切相关，包括额枕下束、钩束和丘脑前放射。这些结果表明，传统的观点的基础上的灰质枢纽（S）的语义加工是不完整的，白色物质在语义认知的作用一直被低估。
Theories about the architecture of language processing differ with regard to whether verbal and nonverbal comprehension share a functional and neural substrate and how meaning extraction in comprehension relates to the ability to use meaning to drive verbal production. We (re-)evaluate data from 17 cognitive-linguistic performance measures of 99 participants with chronic aphasia using factor analysis to establish functional components and support vector regression-based lesion-symptom mapping to determine the neural correlates of deficits on these functional components. The results are highly consistent with our previous findings: production of semantic errors is behaviorally and neuroanatomically distinct from verbal and nonverbal comprehension. Semantic errors were most strongly associated with left ATL damage whereas deficits on tests of verbal and non-verbal semantic recognition were most strongly associated with damage to deep white matter underlying the frontal lobe at the confluence of multiple tracts, including the inferior fronto-occipital fasciculus, the uncinate fasciculus, and the anterior thalamic radiations. These results suggest that traditional views based on grey matter hub(s) for semantic processing are incomplete and that the role of white matter in semantic cognition has been underappreciated.