Encapsulation of Water-Insoluble Drugs in Polymer Capsules Prepared Using Mesoporous Silica Templates for Intracellular Drug Delivery
Encapsulation of Water-Insoluble Drugs in Polymer Capsules Prepared Using Mesoporous Silica Templates for Intracellular Drug Delivery
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DOI：
10.1002/adma.201001497
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发表时间：
2010-10-08
影响因子：
29.4
通讯作者：
Caruso, Frank
中科院分区：
文献类型：
--
作者：
Wang, Yajun;Yan, Yan;Caruso, Frank
水不溶性化合物通过介孔二氧化硅纳米粒子介导的层层组装被封装在聚合物胶囊中。该载药胶囊具有良好的胶体稳定性，体外对大肠癌细胞具有较高的杀伤活性，与溶于有机溶剂的游离药物的细胞毒性相当。
Water-insoluble compounds were encapsulated in polymer capsules through mesoporous silica nanoparticle-mediated layer-by-layer assembly. The drug-loaded capsules exhibit excellent colloidal stability and high potency to colorectal cancer cells in vitro with similar cytotoxicity to the free drug dissolved in organic solvent.