PARABRACHIAL NEURON DISCHARGE IN THE CAT IS ALTERED DURING THE CARBACHOL-INDUCED REM SLEEP-LIKE STATE (DCARB)
PARABRACHIAL NEURON DISCHARGE IN THE CAT IS ALTERED DURING THE CARBACHOL-INDUCED REM SLEEP-LIKE STATE (DCARB)
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DOI：
10.1016/0304-3940(90)90049-f
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发表时间：
1990-12-11
影响因子：
2.5
通讯作者：
LYDIC, R
中科院分区：
文献类型：
--
作者：
GILBERT, KA;LYDIC, R
桥脑臂旁神经元被认为在呼吸和睡眠周期控制中都起着调节作用。在猫的脑桥内侧网状结构(MPRF)微量注射胆碱能激动剂卡巴胆碱产生与快速眼动(REM)睡眠(Neurosci)时观察到的呼吸变化平行的呼吸变化，这一发现鼓舞了他们。102(1989)211-216)，这项研究验证了mPRF中的胆碱能机制也可以引起臂旁神经元放电的状态依赖性变化的假设。本文描述了在REM睡眠和卡巴胆碱诱导的REM睡眠样状态(DCarb)期间臂旁神经元的细胞外记录。在REM期间被激活(REM-ON)或失活(REM-OFF)的细胞在DCarb状态下保持相同的状态依赖的放电模式。这些结果支持这样的假设，即mPRF中的胆碱能机制可以引起臂旁神经元放电的状态依赖性变化。
Pontine parabrachial neurons have been suggested to play a regulatory role in both respiratory and sleep cycle control. Encouraged by the finding that microinjections of the cholinergic agonist carbachol into the medial pontine reticular formation (mPRF) of the cat produced respiratory changes paralleling those observed during rapid eye movement (REM) sleep (Neurosci. Lett., 102 (1989) 211-216), this study tested the hypothesis that cholinergic mechanisms in the mPRF can also cause state-dependent changes in the discharge of parabrachial neurons. This paper describes extracellular recordings of parabrachial neurons during REM sleep and during the carbachol-induced REM sleep-like state (DCarb). Cells which were activated (REM-on) or inactivated (REM-off) during REM maintained these same state-dependent firing patterns during the DCarb state. These results support the hypothesis that cholinergic mechanisms in the mPRF can cause state-dependent changes in the discharge of parabrachial neurons.