Development and validation of a leukocyte-associated immunoglobulin-like receptor-1 prognostic signature for lower-grade gliomas.
Development and validation of a leukocyte-associated immunoglobulin-like receptor-1 prognostic signature for lower-grade gliomas.
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DOI：
10.1002/cam4.4945
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发表时间：
2023-01
期刊：
影响因子：
4
通讯作者：
Wu, Lei
中科院分区：
文献类型：
--
作者：
Fang, Zhansheng;Lin, Li;Tu, Zewei;Zhu, Xingen;Li, Jingying;Luo, Pengxiang;Huang, Kai;Wu, Lei
关键词：
白细胞相关免疫球蛋白样受体-1（LAIR-1）是一种免疫抑制受体，广泛表达于免疫细胞，但LAIR-1在胶质瘤进展中的作用尚不清楚。本研究的目的是使用公开可用的数据集探索LAIR-1表达与低级别胶质瘤（LGG）发展之间的关系。我们利用癌症基因组图谱（TCGA）来分析LGG患者中LAIR-1的表达。其次，使用Kaplan-Meier方法和单变量和多变量考克斯回归分析结合CGGA数据库来检查LAIR-1表达的临床意义，然后使用受试者工作特征曲线分析来验证LAIR-1的预后效用。基因本体论（GO），京都基因和基因组百科全书（KEGG）和基因集富集分析（GSEA）被用来探索LAIR-1的功能。使用ESTIMATE算法和单样本基因集富集分析进行与免疫浸润的相关性分析。我们的研究结果表明，LAIR-1的表达与LGG的恶性临床病理特征呈正相关。单因素分析和多因素分析显示，LAIR-1的过度表达与患者的预后不良相关。结合LAIR-1的诺模图模型更有助于指导临床诊断，功能富集分析显示胶质瘤的恶性发展与肿瘤免疫微环境密切相关。提示LAIR 1是判断LGG患者预后的潜在标志物。LAIR 1还可能通过调节免疫细胞的浸润参与LGG的TIME，提示LAIR 1可能作为调节抗肿瘤免疫应答的治疗靶点。
Leukocyte‐associated immunoglobulin‐like receptor‐1 (LAIR‐1), is an immunosuppressive receptor, widely expressed by immune cells, but the part of LAIR‐1 in glioma progression remains unclear. The purpose of this study was to explore the relationship between LAIR‐1 expression and the development of lower‐grade glioma (LGG) using publicly available data sets. We took advantage of The Cancer Genome Atlas (TCGA) to analyze the expression of LAIR‐1 in patients with LGG. Second, Kaplan‐Meier methods and univariate and multivariate Cox regression analyses were used to examine the clinical significance of LAIR‐1 expression in combination with CGGA databases, and then receiver operating characteristic curve analysis was used to verify the prognostic utility of LAIR‐1. Gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and gene set enrichment analysis (GSEA) were used to explore the function of LAIR‐1. Analysis of the correlation with immune infiltration was conducted using the ESTIMATE algorithm and single sample gene set enrichment analysis. Our results showed that LAIR‐1 expression to be positively correlated with malignant clinicopathologic features of LGG. Univariate analysis and multivariate analysis revealed that overexpression of LAIR‐1 was correlated with a worse prognosis in patients. A nomogram model combining LAIR‐1 was more useful in guiding clinical diagnosis, and functional enrichment analysis showed that malignant development of glioma was closely affiliated with the tumor immune microenvironment. These results indicate that LAIR 1 is a latent marker for determining the prognosis of LGG patients. LAIR 1 may also participate a critical part in TIME of LGG by regulating the infiltration of immune cells, suggesting that LAIR 1 might be used as a therapeutic target to regulate the antitumor immune response.
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影响因子：
7.4
作者：
Galon J;Pagès F;Marincola FM;Angell HK;Thurin M;Lugli A;Zlobec I;Berger A;Bifulco C;Botti G;Tatangelo F;Britten CM;Kreiter S;Chouchane L;Delrio P;Arndt H;Asslaber M;Maio M;Masucci GV;Mihm M;Vidal-Vanaclocha F;Allison JP;Gnjatic S;Hakansson L;Huber C;Singh-Jasuja H;Ottensmeier C;Zwierzina H;Laghi L;Grizzi F;Ohashi PS;Shaw PA;Clarke BA;Wouters BG;Kawakami Y;Hazama S;Okuno K;Wang E;O'Donnell-Tormey J;Lagorce C;Pawelec G;Nishimura MI;Hawkins R;Lapointe R;Lundqvist A;Khleif SN;Ogino S;Gibbs P;Waring P;Sato N;Torigoe T;Itoh K;Patel PS;Shukla SN;Palmqvist R;Nagtegaal ID;Wang Y;D'Arrigo C;Kopetz S;Sinicrope FA;Trinchieri G;Gajewski TF;Ascierto PA;Fox BA
通讯作者：
Fox BA
DOI：
10.1038/s41577-019-0218-4
发表时间：
2020-01
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Kalbasi A;Ribas A
通讯作者：
Ribas A
影响因子：
15.9
作者：
Gu-Trantien, Chunyan;Loi, Sherene;Willard-Gallo, Karen
通讯作者：
Willard-Gallo, Karen
影响因子：
7.2
作者：
Lucarini, Valeria;Ziccheddu, Giovanna;Schiavoni, Giovanna
通讯作者：
Schiavoni, Giovanna
影响因子：
5.5
作者：
Hozo, Iztok;Tsalatsanis, Athanasios;Djulbegovic, Benjamin
通讯作者：
Djulbegovic, Benjamin