Sample size for a dose-response study.
Sample size for a dose-response study.
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DOI：
10.1080/10543409208835027
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发表时间：
1992-01-01
影响因子：
1.1
通讯作者：
Patel, H I
中科院分区：
文献类型：
--
作者：
Patel, H I
本文讨论了剂量-反应曲线为逻辑斯谛模型的剂量-反应研究中的样本量分配方法。该方法基于希望估计产生疗效的剂量的精密度，导致与安慰剂的临床重要差异。最后给出了一个例子来说明该方法。该文件的主要发展是一个二进制的响应，并适当修改为一个连续变量。
This paper deals with a method of sample size allocation for a dose-response study assuming a logistic model for the dose-response curve. The method is based on the precision with which one wishes to estimate the dose that would produce the efficacy resulting in a clinically important difference from a placebo. An example is given to illustrate the methodology. The main development of the paper is for a binary response and is suitably modified for a continuous variable.