Capacitance of Membrane As a Prognostic Indicator of Survival in Head and Neck Cancer.
Capacitance of Membrane As a Prognostic Indicator of Survival in Head and Neck Cancer.
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DOI：
10.1371/journal.pone.0165809
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Morshed K
中科院分区：
文献类型：
--
作者：
Małecka-Massalska T;Mlak R;Smoleń A;Brzozowska A;Surtel W;Morshed K
Evaluation of prognostic value of capacitance of membrane (Cm), parameter measured by bioelectrical impedance (BIA) as an alternative to known clinical factors in patients with Head and Neck Cancer (HNC). A cohort of 75 stage IIIB and IV HNC patients treated in Department of Otolaryngology, Head and Neck Surgery, Medical University of Lublin, Poland were prospectively evaluated. Cm measurements were performed in all patients using a bioelectrical impedance analyzer that was set on a frequency of 50 kHz. Results of Cm measurements were presented in nF. Survival differences were estimated using Kaplan–Meier method. Significantly higher Cm median was noted in well-nourished(n = 45) compared to malnourished (n = 30) patients (1.41 vs 1.01 respectively; p = 0.0009). Established in ROC curves analysis cut-off value (0.743) was characterized by 98% specificity and 37% sensitivity in the detection of malnutrition. Median overall survival (mOS) in the cohort was 32months. At the time of analysis deaths were recorded in 47 cases (62.7%). In patients who had Cm below the level of 0.743 risk of OS shortening was significantly higher than in other patients (12.1 and 43.4 months respectively; HR = 8.47, 95%CI: 2.91–24.66; χ2 = 15.38, p = 0.0001). Cm is a strong, independent prognostic factor in head and neck cancer.
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影响因子：
6.2
作者：
Hui, David;Bansal, Swati;Bruera, Eduardo
通讯作者：
Bruera, Eduardo
影响因子：
19.6
作者：
Maggiore, Q;Nigrelli, S;Michelassi, C
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Michelassi, C
影响因子：
3
作者：
Selberg, O;Selberg, D
通讯作者：
Selberg, D
影响因子：
4.7
作者：
Stern, RG;Milestone, BN;Gatenby, RA
通讯作者：
Gatenby, RA
DOI：
10.1002/hed.23091
发表时间：
2013-08-01
影响因子：
2.9
作者：
Malecka-Massalska, Teresa;Smolen, Agata;Morshed, Kamal
通讯作者：
Morshed, Kamal