Hypnotic drug use among 0-17 year olds during 2004-2011: A nationwide prescription database study
Hypnotic drug use among 0-17 year olds during 2004-2011: A nationwide prescription database study
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DOI：
10.1177/1403494812464446
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发表时间：
2012-12-01
影响因子：
3.4
通讯作者：
Skurtveit, Svetlana
中科院分区：
文献类型：
--
作者：
Hartz, Ingeborg;Furu, Kari;Skurtveit, Svetlana
目的：在0-17岁挪威人中，（a）描述催眠药物使用的患病率、趋势和数量，（B）确定催眠药物使用者中慢性病的患病率，（c）确定催眠药物复发使用的水平（2007-2011年）。方法：数据来自2004-2011年期间的全国挪威处方数据库（NorPD）。结果：在此期间，0-17岁奥尔兹的催眠药物使用从每1000人中的8.9人增加到12.3人，主要是由于褪黑激素的使用增加了一倍。1-2岁儿童中催眠药物使用率最高，为15/1000。褪黑激素的使用从6岁到12岁稳步增加，在男性中最明显。在13至17岁的女性中，催眠药物的使用增加了三倍。褪黑激素是所有催眠药物中最高的年度剂量; 9-13岁男孩的平均每日剂量为360。共有62%和52%的男性和女性催眠药物使用者与慢性病可报销药物共同用药。经常使用的水平（2007-2011年）在男孩中为12%，在女孩中为8%，其中76-77%与慢性病报销药物同时使用。结论：在0-17奥尔兹中，催眠药物的使用有增加的趋势，这主要是由于褪黑激素的使用量越来越大。尽管如此，由于安全性和有效性方面的数据不足，挪威不建议在这个年龄组使用褪黑激素。13至17岁的女性使用催眠药物的人数增加了三倍，值得注意。
Aims: To (a) describe the prevalence, trend, and amount of hypnotic drug use, (b) determine the prevalence of chronic diseases among hypnotic drug users, and (c) determine levels of recurrent hypnotic drug use (2007-2011), among 0-17 year old Norwegians. Methods: Data were obtained from the nationwide Norwegian Prescription Database (NorPD) in the period 2004-2011. Results: Hypnotic drug use in 0-17 year olds increased during the period, from 8.9 to 12.3 per 1000, mainly owing to doubling of melatonin use. Hypnotic drug use peaked at 15 per 1000 among those aged 1-2 years. Melatonin use increased steadily from 6 to 12 years of age, most pronounced in males. Among females, hypnotic drug use increased threefold from 13 to 17 years of age. Melatonin was dispensed in the highest annual amount of all hypnotic drugs; accounting up to a median of 360 defined daily doses in 9-13 year old boys. A total of 62% and 52% of all male and female hypnotic drug users were co-medicated with reimbursable drugs for chronic diseases. Levels of recurrent use (2007-2011) were 12% in boys and 8% in girls, of whom 76-77% were co-medicated with drugs reimbursed for chronic diseases. Conclusions: There is a trend of increasing use of hypnotic drugs among 0-17 year olds, mainly owing to increasing use of melatonin, used in high amounts. Still, melatonin is not recommended in Norway for use in this age group because of insufficient data on safety and efficacy. A threefold increase in hypnotic drugs among females from 13 to 17 years of age warrants attention.