CIRCADIAN RHYTHMOMETRY OF SERUM INTERLEUKIN-2, INTERLEUKIN-10, TUMOR-NECROSIS-FACTOR-ALPHA, AND GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR IN MEN
CIRCADIAN RHYTHMOMETRY OF SERUM INTERLEUKIN-2, INTERLEUKIN-10, TUMOR-NECROSIS-FACTOR-ALPHA, AND GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR IN MEN
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DOI：
10.3109/07420529509064496
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发表时间：
1995-02-01
影响因子：
2.8
通讯作者：
SCHEVING, LE
中科院分区：
文献类型：
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作者：
YOUNG, MRI;MATTHEWS, JP;SCHEVING, LE
测定了9名健康成年男性受试者血清中4种细胞因子[肿瘤坏死因子-α(TNF-α)、白介素2(IL-2)、粒细胞-巨噬细胞集落刺激因子(GM-CSF)和白介素10(IL-IO)]的水平。通过方差分析和/或余弦模型的最小二乘拟合进行的统计评估显示，每个细胞因子的24小时节律显著。虽然血清中IL-2的含量很低，但在中午左右水平波动，形成一个单一的峰值。相反，其他三种细胞因子表现出双相的时间模式。在可检测到肿瘤坏死因子-α水平的受试者中，第一个峰值出现在07：30，第二个峰值出现在13：30。IL-10水平也呈双相变化，一个峰值在07：30，第二个峰值在12小时后19：30。GM-CSF水平最后一次上升，大约在13：30左右达到峰值，然后在19：30再次达到峰值。这些结果表明，每种细胞因子的时间模式都是独一无二的，通常有白天的高点和夜间的低谷。
Serum levels of four cytokines [tumor necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2), granulocyte-macrophage colony-stimulating factor (GM-CSF), and interleukin-10 (IL-IO)] were measured in nine diurnally active healthy adult male subjects at 3-h intervals during a 24-h period. Statistical evaluation by analysis of variance and/or the least- squares fit of a cosine model revealed significant 24-h rhythms for each cytokine. Although the amount of IL-2 in the serum was low, the levels fluctuated to form a single peak at approximately noon. In contrast, the other three cytokines exhibited a biphasic temporal pattern. In subjects with detectable TNF-alpha levels, the first peak occurred at 07:30 and the second at 13:30. IL-10 levels also exhibited a biphasic pattern, with one peak at 07:30 and the second 12 h later at 19:30. GM-CSF levels were last to rise, first peaking at similar to 13:30 and then again at 19:30. These results suggest temporal patterns that are unique for each cytokine, generally with daytime highs and nighttime lows.