pH-Triggered Controlled Drug Release from Mesoporous Silica Nanoparticles via Intracelluar Dissolution of ZnO Nanolids
pH-Triggered Controlled Drug Release from Mesoporous Silica Nanoparticles via Intracelluar Dissolution of ZnO Nanolids
复制标题
pH 触发通过 ZnO 纳米粒子的细胞内溶解从介孔二氧化硅纳米粒子中控制药物释放
DOI：
10.1021/ja200328s
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发表时间：
2011-06-15
影响因子：
15
通讯作者：
Zhu, Guangshan
中科院分区：
文献类型：
--
作者：
Muharnmad, Faheem;Guo, Mingyi;Zhu, Guangshan
酸可分解的发光ZnO量子点（QD）已被用于密封介孔二氧化硅纳米颗粒（MSNs）的纳米孔，以抑制药物（阿霉素）的过早释放。在内化到HeLa细胞中之后，ZnO QD盖快速溶解在酸性细胞内区室中，并且因此，负载的药物从MSN释放到胞质溶胶中。ZnO量子点表现为一种双重用途的实体，不仅作为盖子，而且对癌细胞具有协同抗肿瘤作用。我们预计，这些纳米粒子可能被证明是一个重要的一步，朝着发展的pH敏感的药物输送系统，最大限度地减少药物毒性。
Acid-decomposable, luminescent ZnO quantum dots (QDs) have been employed to seal the nanopores of mesoporous silica nanoparticles (MSNs) in order to inhibit premature drug (doxorubicin) release. After internalization into HeLa cells, the ZnO QD lids are rapidly dissolved in the acidic intracellular compartments, and as a result, the loaded drug is released into the cytosol from the MSNs. The ZnO QDs behave as a dual-purpose entity that not only acts as a lid but also has a synergistic antitumor effect on cancer cells. We anticipate that these nanoparticles may prove to be a significant step toward the development of a pH-sensitive drug delivery system that minimizes drug toxicity.