Sympathetic vasomotor outflow during low‐intensity leg cycling in healthy older males
Sympathetic vasomotor outflow during low‐intensity leg cycling in healthy older males
复制标题
健康老年男性低强度腿部循环期间交感神经血管舒缩流出
DOI：
10.1113/ep090497
复制
发表时间：
2022
影响因子：
2.7
通讯作者：
Ogoh Shigehiko
中科院分区：
文献类型：
--
作者：
Katayama Keisho;Saito Mitsuru;Ishida Koji;Shimizu Kaori;Shiozawa Kana;Mizuno Sahiro;Ogoh Shigehiko
新发现本研究的中心问题是什么？年轻人在低强度动态腿部运动中交感神经血管流出减少：衰老是否影响低强度腿部自行车运动中的交感神经抑制效应？主要发现及其重要性是什么？在低强度骑自行车期间，老年男性的肌肉交感神经活动减少，与年轻男性相同。这是可能的，心肺压力感受器反射介导的抑制交感神经血管流出动态腿部exercise是保存在健康的老年male.AbstractMuscle交感神经活性（MSNA）在低强度动态腿部锻炼在年轻男性减少。这表明，这种抑制是介导的心肺压力感受器的负荷。本研究的目的是阐明年龄对动态腿部运动中MSNA的影响。9名年轻男性（YM，平均值± SD，20 ± 1岁）和9名老年男性（OM，72 ± 3岁）完成了研究。受试者在半卧位使用自行车测力计以10%的心率储备进行两次4分钟的自行车运动（MSNA和估计中心静脉压（eCVP）试验）。通过左侧桡神经的显微神经造影术记录MSNA。基于外周静脉压估计CVP，使用右肘前大静脉插管监测外周静脉压。与YM（+2.8 ± 4.7 mmHg）相比，OM（+9.3 ± 5.5 mmHg）在腿部骑行期间平均动脉血压升高幅度更大。在YM（-8.1 ± 3.8 bursts/min）和OM（-10.6 ± 3.3 bursts/min）中，MSNA爆发频率在循环期间均降低，但两组之间没有发现显著差异。两组运动时eCVP均增加，YM组（+1.1 ± 0.4mmHg）与OM组（+1.2 ± 0.7mmHg）的eCVP变化无差异。这些数据表明，在低强度循环期间，OM中出现交感神经血管流出抑制，如YM中所见。在健康老年男性中，肌肉泵诱导的心肺压力感受器反射负荷可能在骑自行车期间得以保留。
New FindingsWhat is the central question of this study?Sympathetic vasomotor outflow is reduced during low‐intensity dynamic leg exercise in younger individuals: does ageing influence the sympathoinhibitory effect during low‐intensity leg cycling?What is the main finding and its importance?Muscle sympathetic nerve activity during low‐intensity cycling decreased in older males, as seen in young males. It is possible that cardiopulmonary baroreflex‐mediated inhibition of sympathetic vasomotor outflow during dynamic leg exercise is preserved in healthy older males.AbstractMuscle sympathetic nerve activity (MSNA) is reduced during low‐intensity dynamic leg exercise in young males. It is suggested that this inhibition is mediated by loading of the cardiopulmonary baroreceptors. The purpose of this study was to clarify the impact of age on MSNA during dynamic leg exercise. Nine younger males (YM, mean ± SD, 20 ± 1 years) and nine older males (OM, 72 ± 3 years) completed the study. The subjects performed two 4‐min cycling exercises at 10% of their heart rate reserve using a cycle ergometer in a semirecumbent position (MSNA and estimated central venous pressure (eCVP) trials). MSNA was recorded via microneurography of the left radial nerve. The CVP was estimated based on peripheral venous pressure, which was monitored using a cannula in the right large antecubital vein. The magnitude of the increase in mean arterial blood pressure during leg cycling was larger in OM (+9.3 ± 5.5 mmHg) compared with YM (+2.8 ± 4.7 mmHg). MSNA burst frequency was decreased during cycling in both YM (–8.1 ± 3.8 bursts/min) and OM (–10.6 ± 3.3 bursts/min), but no significant difference was found between the two groups. The eCVP increased during exercise in both groups, and there was no difference in the changes in eCVP between YM (+1.1 ± 0.4 mmHg) and OM (+1.2 ± 0.7 mmHg). These data indicate that inhibition of sympathetic vasomotor outflow during low‐intensity cycling appears in OM as seen in YM. It is possible that the muscle pump‐induced loading of the cardiopulmonary baroreflex is preserved during cycling in healthy older males.