Parity as a prognostic factor in young breast cancer patients.
Parity as a prognostic factor in young breast cancer patients.
复制标题
产次作为年轻乳腺癌患者的预后因素。
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
T. Barclay
中科院分区：
文献类型：
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作者：
M. Black;B. Hankey;T. Barclay
资料分析了219名女性乳腺癌患者不到36岁的诊断和治疗在萨斯喀彻温省，加拿大，在1946年至1972年。其中171名患者的病理切片可供审查，136名患者可被确认为浸润性乳腺癌。对于总患者组和经病理检查证实为浸润性癌的患者，未生育患者的年龄校正生存率高于经产患者。潜在的混杂因素的调整表明，在很大程度上，可以解释的分布在节点状态和原发性肿瘤的核分级的差异，在奇偶组之间的生存差异。由于这些因素与乳腺癌的生物学行为有关，并且这些因素的分布与分析中使用的产次类别显著相关，因此数据提供了一些证据，表明产次影响年轻女性乳腺癌的行为。
Data were analyzed concerning 219 female breast cancer patients less than 36 years of age who were diagnosed and treated in the Province of Saskatchewan, Canada, during 1946-72. Pathology slides were available for review on 171 of these patients, and invasive breast cancer could be confirmed in 136. Nulliparous patients had more favorable age-adjusted survival rates than parous patients for the total patient group and for those patients whose tumor was verified to be invasive cancer on pathologic review. Adjustment for potential confounding factors indicated that differences in survival among parity groups could be explained to a substantial degree by differences in distribution over node status and the nuclear grade of the primary tumor. Because these factors relate to the biologic behavior of breast cancer and because the distributions of these factors were significantly associated with the parity categories utilized in the analysis, the data provide some evidence that parity influences the behavior of breast cancer in young women.