How to perform and analyse synovial biopsies
How to perform and analyse synovial biopsies
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DOI：
10.1016/j.berh.2013.03.006
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发表时间：
2013-04-01
影响因子：
5.2
通讯作者：
Tak, Paul P.
中科院分区：
文献类型：
--
作者：
Gerlag, Danielle M.;Tak, Paul P.
虽然大多数风湿性疾病可以根据临床检查结合实验室和放射学检查来诊断，但滑膜组织的组织学检查可能有助于正确诊断和调整治疗方案，当怀疑滑液培养阴性的肿瘤性或肉芽肿性疾病、沉积性疾病或感染时。为了研究目的，滑膜组织分析被用来研究滑膜的病理变化，旨在阐明关节炎的病因学和发病机制。此外，滑膜生物标记物的使用已被证明在新疗法的发展过程中起到了重要作用。在这一章中，描述了几种获取滑膜组织样本的微创技术、组织的处理和分析。(C)2013爱思唯尔有限公司。保留所有权利。
Although most of the rheumatologic diseases can be diagnosed based on clinical examination combined with additional laboratory and radiographic tests, histological examination of synovial tissue may lead to the correct diagnosis and adjustment of therapy when neoplastic or granulomatous disease, deposition disease or infection in spite of negative synovial fluid culture is suspected. For research purposes synovial tissue analysis is used to investigate the pathological changes of the synovium in studies aimed at elucidating the aetiology and pathogenetic mechanisms involved in arthritis. In addition, the use of synovial biomarkers has been shown to be instrumental in the developmental process of new therapeutics. In this chapter, several minimally invasive techniques for acquiring synovial tissue samples, handling of the tissue and the analysis thereof are described. (C) 2013 Elsevier Ltd. All rights reserved.