Membrane effects of ethanol: bulk lipid versus lipid domains.
Membrane effects of ethanol: bulk lipid versus lipid domains.
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乙醇的膜效应：大量脂质与脂质域。
DOI：
10.1016/0024-3205(88)90147-6
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发表时间：
1988
期刊：
影响因子：
6.1
通讯作者：
Schroeder,F
中科院分区：
文献类型：
--
作者：
Wood,WG;Schroeder,F
已经确定的是，乙醇使膜的大量脂质流体化，并且这种作用可能改变细胞功能并涉及乙醇敏感性和耐受性。这一假设得到了几项研究的支持，然而，也有相当数量的数据不支持这种解释，例如，乙醇对蛋白质的直接影响、其他膜作用药物、温度影响、乙醇对老化膜的影响以及长期乙醇消耗对脂质含量的不一致影响。本综述研究了散装膜流化假说，根据这些数据，并提出了修改的散装膜假说，是基于最近的数据表明，乙醇和其他醇类有一个特定的影响，不同的膜域的结构特性。乙醇的这种特定的影响进行了讨论的范围内的流动性的变化域可能会改变膜功能。
It has been well-established that ethanol fluidizes the bulk lipid of membranes and that this effect may alter cell function and be involved in ethanol sensitivity and tolerance. This hypothesis has been supported in several studies, however, there is also a considerable amount of data that do not support such an explanation, e.g., direct effect of ethanol on proteins, other membrane acting drugs, temperature effects, effects of ethanol on aged membranes and inconsistent effects of chronic ethanol consumption on lipid content. This review examined the bulk membrane fluidization hypothesis in light of those data and proposed a modification of the bulk membrane hypothesis that is based on recent data that show that ethanol and other alcohols have a specific effect on the structural properties of different membrane domains. This specific effect of ethanol is discussed within the context of how changes in fluidity of domains may alter membrane function.