Is It Time to Retire the Low-Oxalate Diet? No!
Is It Time to Retire the Low-Oxalate Diet? No!
复制标题
是时候放弃低草酸盐饮食了吗？
DOI：
10.1089/end.2021.0576
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发表时间：
2021
影响因子：
2.7
通讯作者：
Assimos,DeanG
中科院分区：
文献类型：
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作者：
Crivelli,JosephJ;Wood,KyleD;Assimos,DeanG
大约十分之一的人患有肾结石，草酸钙是最常见的肾结石成分。尿液中草酸盐的含量是草酸钙结石形成的关键决定因素。尿草酸盐所带来的风险已被证明是一个连续的变量，随着草酸盐排泄量的增加，结石形成的风险也随之增加，即使在低于高草酸尿的水平时也是如此。简单地说，尿中没有草酸盐，就没有草酸钙结石病。饮食中草酸盐的摄入显著影响尿中草酸盐的排泄，这是草酸钙结石形成患者可控制的一个因素。考虑到饮食中草酸盐的重要作用以及肾结石疾病在美国的发病率和患病率不断上升，3现在不是退出低草酸盐饮食的时候。我们描述了饮食草酸与尿草酸和草酸钙肾结石形成的关系，以及低草酸饮食在肾结石预防中的关键作用。
Approximately 1 in 10 individuals is afflicted with kidney stone disease, 1 and calcium oxalate is the most common kidney stone composition. 2 The amount of oxalate in the urine is a key determinant of calcium oxalate stone formation. The risk imparted by urinary oxalate has been demonstrated to be a continuous variable, with risk of stone formation increasing along with increases in oxalate excretion, even at levels below what is defined as hyperoxaluria. Simply put, without oxalate in the urine, there is no calcium oxalate stone disease. Dietary oxalate intake contributes significantly to urinary oxalate excretion, and this is a factor that is within calcium oxalate stone forming patients’ control. Considering the important role of dietary oxalate and the rising incidence and prevalence of kidney stone disease in the United States, 3 now is not the time to retire the low-oxalate diet. We describe dietary oxalate’s relationship to urinary oxalate and calcium oxalate kidney stone formation, and the critical role of the low-oxalate diet in kidney stone prevention.