Impaired myocardial 123I-metaiodobenzylguanidine uptake in Lewy body disease:: Comparison between dementia with Lewy bodies and Parkinson's disease
Impaired myocardial 123I-metaiodobenzylguanidine uptake in Lewy body disease:: Comparison between dementia with Lewy bodies and Parkinson's disease
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DOI：
10.1016/j.jns.2005.08.011
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发表时间：
2006-01-15
影响因子：
4.4
通讯作者：
Inoue, K
中科院分区：
文献类型：
--
作者：
Suzuki, M;Kuriita, A;Inoue, K
背景资料：应用~（123）I标记间碘苄胍（I-123-MIBG）心肌显像评价Lewy小体病（LBD）包括帕金森病（PD）和Lewy小体痴呆（DLB）患者的心脏交感神经支配。LBD患者心脏MIBG蓄积显著减少，表明心脏交感神经系统严重受损。目的：比较123-MIBG心功能显像对DLB和PD患者早期心交感神经功能的影响。对22例早期DLB患者进行了I-123-MIBG心肌显像，41例早期特发性PD患者和15例年龄和病程匹配的正常对照受试者。结果：早期DLB患者心肌I-123-MIBG摄取明显低于对照组，H/M比值明显低于PD患者，与Hoehn和Yahr分期无关。我们的研究结果表明，心脏交感神经功能在DLB严重受损，即使在疾病的早期阶段。(c)2005 Elsevier B.V保留所有权利。
Background: Iodine-123-labeled metaiodobenzylguanidine (I-123-MIBG) myocardial scintigraphy has been used to evaluate cardiac sympathetic denervation in Lewy body disease (LBD) including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Patients with LBD had marked reductions in cardiac MIBG accumulation, indicative of severe impairment of the cardiac sympathetic nervous systems. However, the differences in scintigraphy between DLB and PD have not been determined.Objective: To compare cardiac sympathetic function in early disease stage measured with I-123-MIBG scintigraphy between DLB and PD.Methods: I-123-MIBG myocardial scintigraphy was performed in 22 patients with early-stage DLB, 41 patients with early idiopathic PD and 15 normal control subjects who were matched for age and disease duration. The heart-to-mediastinum (H/M) ratio was calculated.Results: I-123-MIBG uptake of the myocardium Was Significantly lower in patients with early DLB than in controls, The mean value of H/M ratio in patients with DLB was significantly lower than those in patients with PD, independent of the Hoehn and Yahr stage.Conclusions: Our findings suggest that cardiac sympathetic function in DLB is severely impaired even in the early disease stage. (c) 2005 Elsevier B.V All rights reserved.