Slc26a3 (DRA) in the Gut: Expression, Function, Regulation, Role in Infectious Diarrhea and Inflammatory Bowel Disease
Slc26a3 (DRA) in the Gut: Expression, Function, Regulation, Role in Infectious Diarrhea and Inflammatory Bowel Disease
复制标题
Slc26a3 (DRA) 在肠道中的表达、功能、调节以及在感染性腹泻和炎症性肠病中的作用
DOI：
10.1093/ibd/izaa256
复制
发表时间：
2020
影响因子：
4.9
通讯作者：
余琴
中科院分区：
文献类型：
--
作者：
余琴
研究背景Cl-和HCO 3-的跨上皮转运对肠上皮细胞的功能和维持酸平衡至关重要。Slc 26 a3（CCl 26 a3）是肠上皮细胞腔膜上的一种重要的氯-碳酸氢盐交换蛋白，与Na+/H+交换蛋白共同参与肠对电中性NaCl的吸收。最近越来越多的证据支持Slc 26 a3的功能或表达降低在感染性腹泻和炎症性肠病（IBD）中的重要作用。更好地了解Slc 26 a3在感染性腹泻和IBD的生理和病理生理相关性可能揭示未来therapeutic.ConclusionUnderstanding的生理功能，调节相互作用，和潜在的机制Slc 26 a3在感染性腹泻和IBD的病理生理学将定义新的治疗方法在未来。
BackgroundThe transport of transepithelial Cl-and HCO3-is crucial for the function of the intestinal epithelium and maintains the acid-based homeostasis. Slc26a3 (DRA), as a key chloride-bicarbonate exchanger protein in the intestinal epithelial luminal membrane, participates in the electroneutral NaCl absorption of intestine, together with Na+/H+exchangers. Increasing recent evidence supports the essential role of decreased DRA function or expression in infectious diarrhea and inflammatory bowel disease (IBD).MethodIn this review, we give an overview of the current knowledge of Slc26a3, including its cloning and expression, function, roles in infectious diarrhea and IBD, and mechanisms of actions. A better understanding of the physiological and pathophysiological relevance of Slc26a3 in infectious diarrhea and IBD may reveal novel targets for future therapy.ConclusionUnderstanding the physiological function, regulatory interactions, and the potential mechanisms of Slc26a3 in the pathophysiology of infectious diarrhea and IBD will define novel therapeutic approaches in future.