Wheat bran and soy protein feeding do not alter urinary excretion of the isoflavan equol in premenopausal women
Wheat bran and soy protein feeding do not alter urinary excretion of the isoflavan equol in premenopausal women
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DOI：
10.1093/jn/131.3.740
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发表时间：
2001-03-01
影响因子：
4.2
通讯作者：
Chen, C
中科院分区：
文献类型：
--
作者：
Lampe, JW;Skor, HE;Chen, C
在体内将大豆异黄酮转化为雌马酚的能力可能是由个体的肠道微生物群落决定的;然而，饮食也可能影响这种转化。本研究的目的是确定是否1个月的膳食纤维补充麦麸增加尿雌马酚排泄物中的雌马酚排泄和刺激非排泄物中的雌马酚产生，以及长期大豆蛋白摄入是否增加雌马酚产生或改变总体尿雌马酚排泄。首先，我们筛选了74名年龄在20-40岁的妇女，并确定了她们的雌马酚排泄状态。在这些妇女中，健康和生活方式模式和习惯性饮食摄入量没有根据雌马酚排泄状态而不同。接下来，26名女性（13名雌马酚排泄者和13名非排泄者）被分配（阻断雌马酚排泄状态）长期（1个月）或短期（4天）大豆蛋白补充剂。在每个大豆治疗组中，妇女参加了两个1个月的干预期（确切的长度由每个妇女的月经周期决定），在此期间，她们在随机交叉设计中每天食用0或16 g膳食纤维补充的日常饮食。1个月的洗脱期将两个饮食阶段分开。在完成两个时期的19名妇女中，补充纤维并没有增加雌马酚排泄物或非排泄物的雌马酚产量。此外，雌马酚的排泄量并没有因纤维剂量或大豆干预的时间长短而有所不同。这些结果表明，每日16克纤维剂量（如麦麸）和添加大豆蛋白不会显著改变结肠微生物菌群产生雌马酚的能力。
The capacity to convert the soy isoflavone daidzein to equol in vivo is presumably determined by an individual's intestinal microfloral populations; however, diet may also influence this conversion. The objectives of the present study were to determine whether a 1-mo supplementation of dietary fiber as wheat bran increases urinary equol excretion in equol excreters and stimulates equol production in nonexcreters and whether longer-term soy isoflavone intake increases equol production or alters overall urinary isoflavone excretion. First, we screened 74 women, ages 20-40 y, and determined their equol-excreter status. In these women, health and lifestyle patterns and habitual dietary intake did not differ according to equol-excreter status. Next, 26 of the women (13 equol excreters and 13 nonexcreters) were assigned (blocked on equol-excreter status) to either longer-term (1 mo) or short-term (4 d) soy protein supplementation. Within each soy treatment group, women participated in two 1-mo intervention periods (the exact length was determined by each woman's menstrual cycle) during which they consumed their usual diets supplemented daily with either 0 or 16 g dietary fiber in a randomized crossover design. A 1-mo washout period separated the two diet periods. Among the 19 women who completed both periods, fiber supplementation did not increase equol production in equol excreters or nonexcreters. In addition, isoflavonoid excretion did not differ by fiber dose or length of soy intervention These results suggest that a daily 16 g-fiber dose as wheat bran and the addition of soy protein do not alter significantly the capacity of colonic microflora to produce equol.