Cloning and expression of CSAL2, a new member of the spalt gene family in chick
Cloning and expression of CSAL2, a new member of the spalt gene family in chick
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DOI：
10.1016/s0925-4773(01)00296-9
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发表时间：
2001-04-01
影响因子：
2.6
通讯作者：
Münsterberg, AE
中科院分区：
文献类型：
--
作者：
Farrell, ER;Tosh, G;Münsterberg, AE
在这项研究中，我们描述了克隆和表达CSAL 2，鸡spalt基因家族的第二个成员。所有的spalt蛋白的特点是存在多个锌指基序，这是高度保守的。人类spalt基因HSAL 1突变导致Towns-Brocks综合征（TBS）。我们在这里表明，CSAL 2在TBS中受影响的许多组织中表达，包括神经组织、肢芽、中肾和泄殖腔。(C)2001爱思唯尔科学爱尔兰有限公司保留所有权利。
In this study we describe cloning and expression of CSAL2, a second member of the spalt gene family in chick. All spalt proteins are characterized by the presence of multiple zinc-finger motifs, which are highly conserved. Mutations in HSAL1, a human spalt gene result in Townes-Brocks syndrome (TBS). We show here that CSAL2 is expressed in many of the tissues affected in TBS, including neural tissue, limb buds, mesonephros and cloaca. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.