Systematic Review and Meta-Analysis of Early-Life Exposure to Bisphenol A and Obesity-Related Outcomes in Rodents.
Systematic Review and Meta-Analysis of Early-Life Exposure to Bisphenol A and Obesity-Related Outcomes in Rodents.
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DOI：
10.1289/ehp1233
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发表时间：
2017-10-05
影响因子：
10.4
通讯作者：
Legler J
中科院分区：
文献类型：
--
作者：
Wassenaar PNH;Trasande L;Legler J
早年接触双酚A(BPA)被认为在肥胖的发生中起着一定的作用。对实验性啮齿动物研究进行了系统的综述和荟萃分析，以回答以下问题：早期暴露于双酚A是否影响肥胖相关结局：体重、脂肪(PAD)重量以及循环和组织中甘油三酯、游离脂肪酸(FFA)和瘦素的水平？该方法是使用实验室动物实验系统评价中心(SYRCLE)方法在严格的方案中预先指定的。利用PubMed和EMBASE，我们确定了61篇符合纳入标准的文章。使用SYRCLE偏差风险工具评估这些文章的偏差风险和方法质量，并使用置信度评级方法对证据质量进行评分。使用随机效应模型进行Meta分析，并计算标准化平均差异(SMDS)，或在可能的情况下计算平均差异(MD)。总体评估显示，BPA与脂肪重量[(95%CI：0.53，0.81)]、甘油三酯[(95%CI：0.53，1.40)]和游离脂肪酸[(95%CI：0.50，1.22)]显著正相关，与瘦素水平[(95%CI：0.87)]无显著正相关，与体重显著负相关[(95%CI：，)]。亚组分析显示，在男性中，与高于参考剂量的剂量相比，低于当前美国参考剂量的剂量与大多数结果指标有更强的正相关性。应该指出的是，所有被评估的结果在不同的研究中都有很大的异质性，而且没有足够的信息来评估大多数研究的偏倚风险。我们系统综述的结果表明，早期暴露于双酚A可能会增加啮齿动物的肥胖和循环血脂水平。Https://doi.org/10.1289/EHP1233
Early-life exposure to bisphenol A (BPA) has been implicated to play a role in the development of obesity. A systematic review with meta-analyses of experimental rodent studies was conducted to answer the following question: does early-life exposure to BPA affect the obesity-related outcomes body weight, fat (pad) weight, and circulating and tissue levels of triglycerides, free fatty acids (FFA), and leptin? The methodology was prespecified in a rigorous protocol using the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) approach. Using PubMed and EMBASE, we identified 61 articles that met the inclusion criteria. The risk of bias and the methodological quality of these articles were assessed using the SYRCLE Risk of Bias tool, and a confidence-rating methodology was used to score the quality of evidence. Meta-analyses were performed using random effect models and standardized mean differences (SMDs), or, where possible, mean differences (MDs) were calculated. Overall summary estimates indicated significant positive associations between BPA and fat weight [ (95% CI: 0.53, 0.81)], triglycerides [ (95% CI: 0.53, 1.40)], and FFA [ (95% CI: 0.50, 1.22)], and a nonsignificant positive association with leptin levels [ (95% CI: , 0.87)] and a significant negative association with body weight were estimated [ (95% CI: , )]. Subgroup analyses revealed stronger positive associations for most outcome measures in males and at doses below the current U.S. reference dose of compared with doses above the reference dose. It should be noted that there was substantial heterogeneity across studies for all outcomes assessed and that there was insufficient information to assess risk of bias for most studies. Findings from our systematic review suggest that early-life exposure to BPA may increase adiposity and circulating lipid levels in rodents. https://doi.org/10.1289/EHP1233