Familial aggregation in skin flush response to niacin patch among schizophrenic patients and their nonpsychotic relatives
Familial aggregation in skin flush response to niacin patch among schizophrenic patients and their nonpsychotic relatives
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DOI：
10.1093/schbul/sbl038
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发表时间：
2007-01-01
影响因子：
6.6
通讯作者：
Chen, Wei J.
中科院分区：
文献类型：
--
作者：
Lin, Sheng-Hsiang;Liu, Chih-Min;Chen, Wei J.
虽然在精神分裂症患者中发现了对烟酸的潮红反应降低，但它是否是精神分裂症的易感性指标仍然知之甚少。我们的目的是研究精神分裂症患者及其非精神病亲属烟酸潮红反应的家族聚集性。在153名精神分裂症先证者、217名父母、70名兄弟姐妹和94名正常受试者的样本中，将3种浓度（0.001 M、0.01 M和0.1 M）的烟酸应用于前臂皮肤，分别在5、10和15分钟时用4分量表评定潮红反应。对精神分裂症患者的非精神病性亲属中持续潮红评分的遗传度和二元非潮红反应的复发风险比进行了估计，并对先证者亲属的烟酸反应进行了有序logistic回归分析，以调整潜在的混杂因素。最大的遗传力范围为47%（0.01 M在10分钟）至54%（0.1 M在5分钟）。在10分钟（从使用1分或更低评分的2.60到使用0分作为非冲洗的5.06）和5分钟（使用0分作为非冲洗的1.66）时0.01 M的风险比显著大于1。多元有序logistic回归分析进一步显示，在调整潜在混杂因素（包括年龄、性别、过敏、吸烟和喝咖啡）后，先证者和亲属之间在烟酸潮红反应方面的相关性仍然存在。这些研究结果为烟酸潮红反应作为精神分裂症易感性指标的潜力提供了支持。
Though a reduced flush response to niacin has been found in schizophrenic patients, whether it is a vulnerability indicator to schizophrenia remains little known. We aimed to examine the familial aggregation in niacin flush response among schizophrenic patients and their nonpsychotic relatives. In a sample of 153 schizophrenia probands, 217 parents, 70 siblings, and 94 normal subjects, 3 concentrations (0.001 M, 0.01 M, and 0.1 M) of niacin were applied to the forearm skin and the flush response was rated at 5, 10, and 15 minutes, respectively, with a 4-point scale. Both the heritability for continuous flush scores and the recurrence risk ratios for binary nonflush response in the nonpsychotic relatives of schizophrenic patients were estimated, and ordinal logistic regression analyses of relatives' niacin response on probands' were further conducted to adjust for potential confounders. The greatest heritabilities ranged from 47% (0.01 M at 10 minutes) to 54% (0.1 M at 5 minutes). The risk ratios of 0.01 M at 10 minutes (ranging from 2.60 for using score 1 or less to 5.06 for using score 0 as nonflush) and 5 minutes (1.66 for using score 0 as nonflush) were significantly greater than one. Multiple ordinal logistic regression analyses further revealed that the association between probands and relatives in niacin flush response remained after adjustment for potential confounders, including age, sex, allergy, tobacco smoking, and coffee drinking. These findings provide support for the potential of niacin flush response as a vulnerability indicator to schizophrenia.